Reported by the clinician STOPP trial results, published last month in the prestigious journal of the American College of Rheumatology (ACR), Arthritis & Rheumatism
This international study, which has enjoyed the participation of 622 patients with osteoarthritis of the knee, provides a crucial development because it shows that condroitn sulfate prevents reduction in the intraarticular space significantly and, therefore, is effective in controlling the degenerative process of osteoarthritis.
Condroitn sulfate, given daily for two years at a dose of 800 mg, reduces prdida intraarticular space that occurs in osteoarthritis of the knee. An encouraging fact that the study shows STOPP (Study on Osteoarthritis Progression Prevention) published in February the number of n1 in rheumatologist magazine, Arthritis & Rheumatism.
Diminish the joint space significantly less in the CS group (-0.07 0.03 mm) versus placebo (-0.31 0.04 mm) between the start and end of the study [p <0.0001].
In addition, this study confirms the effect sintomtico sulfate condroitn slow because patients treated with the study were reduced in frmaco chondroprotection comparacin pain with placebo.
Condroitn sulfate also showed tolerability and adverse effects rate similar to placebo. The majority of adverse effects were transient and mild.
Characteristics of the study
STOPP study, led by Dr. Andre Kahan (University Paris Descartes), include 622 subjects with knee osteoarthritis of both sexes and aged between 45 and 80 years. All persons included in the trial received chondroitin sulfate or placebo daily for 2 years. The study, randomized and double blind, concludes that condroitn sulfate significantly reduces radiolg progresin derivative of osteoarthritis.
Condroitn Sulfate
The Condroitn sulfate is an important component of the majority of vertebrate tissues. Part of glycosaminoglycans, which are important structural constituents of the extracellular matrix of cartlago. Condroitn sulfate is a chondroprotection frmaco of deed sintomtica slow that record in the 3 structures affected in osteoarthritis: cartlago, synovium and subchondral bone.
Efficacy and Safety of condroitn sulfate have been confirmed with the results of studies clinician and with the support of institutions MXIM 'scientific rigor, such as:
Condroitn sulfate disminucin is effective in improving pain and mobility associated with the disease artrsica:
or 5 studies versus placebo
or 2 studies versus NSAIDs
3 metaanlisis
Condroitn sulfate can control progresin of osteoarthritis.
or 6 studies versus placebo
1 metaanlisis
Condroitn sulfate has a higher security level higher than the Classics therapy (analgsicos or inflammatory) and similar to placebo.
Condroitn sulfate does not interact with other frmacos (ideal for patients with polypharmacy) without being metabolized by cytochrome P450.
Est Condroitn sulfate indicated for use in patients with WHO joints (knee, finger and hip).
EULAR recommendations for the treatment of osteoarthritis of the knee measured at the evidence condroitn ms sulfate high (1A), the highest level of recomendacin (A) and the best safety profile.
The guages of OARSI, appeared in the year 2008, appears condroitn sulfate between treatments with a greater effect dick size and level of evidence 1A.
Reported Espaola Society of rheumatologists (SER), the sulfate condroitn: Decreases pain and improves mobility, reduces the need for NSAIDs and may analgsicos and control of osteoarthritis progresin , otorgndole the degree of recomendacin A and the level of evidence 1A.
All these data suggest that was est entering a new era of osteoarthritis TERAPUTICO to have that treat frmacos raz base or disease. In addition, they improve the quality of life of patients and artrsicos important reduccin cost Crnica involved in this disease. Thus, the chondro therapy must be based treatment of osteoarthritis (both in their prevention introduced as in osteoarthritis).
Wednesday, September 2, 2009
SENER manufacture and market a robot for surgery laparoscpica voice guidance.
The company SENER Engineering and Systems, SA has licensed manufacturer of medical devices for the Wizard industrializacin Robot Surgeries Laparoscpica. The robot, which won the Award for Best Inventium patent in 2007, is a system that positions the laparoscope in the abdominal cavity of the patient, following the commands given by the surgeon's voice.
The Assistant Robot frees the surgeon from the task of sujeciny CMAR guidance of the laparoscope and five degrees of freedom allow you to mimic the motions of this activity. Being an automatic system for precision the position of the Chamber is totally stable, providing a high quality image to the surgeon who runs the operation. The robot is porttil not need ningn type of installation in quirfano or anchors the operating table and has a large autonomous, allowing you to tackle long-duration operations.
The engineer company Espaa be the first to manufacture this type of robots
The company IT company has applied its experience in control systems for precision actuaciny to develop this product into your System Practitioners Online surveys. The health license issued by the Agency Espaola Medicines and Health Products, is the first granted by this body for a robot of these Features. With it the company will manufacture and market the Robot to Aid in Surgeries Laparoscpica, first manufactured in spain.
As a next step in the marketing of this robot SENER, as exclusive licensee of the patent system espaola attendance robotics invasive cirugamnimamente capable of positioning an instrument in response to quirrgico AYMENT ORDERS fijacina a surgeon without the operating table or after calibracin insertion point, has requested the International Extension of the patent within the European Community, Norteamrica and Asia.
About SENER Engineering and Systems, SA
SENER is an engineering company, Consulting & integration of systems that now gives it an international reference in the ares of Aerospace Engineering, Civil and Architecture, Engineering Processes and Naval Energay . It has a staff of 2,000 ms facturacin employees and more than 350 million. It currently has offices in Madrid, Barcelona, Bilbao, Valencia, Seville, Algiers, Buenos Aires, Lisbon, Mxico DF, Okayama (Japn), San Francisco and Warsaw. Ingenieray SENER SENER Systems is part of Group Engineering, one of the largest engineering groups spaniards, with 4,500 ms and a facturacin exceeding 753 million euros.
The Assistant Robot frees the surgeon from the task of sujeciny CMAR guidance of the laparoscope and five degrees of freedom allow you to mimic the motions of this activity. Being an automatic system for precision the position of the Chamber is totally stable, providing a high quality image to the surgeon who runs the operation. The robot is porttil not need ningn type of installation in quirfano or anchors the operating table and has a large autonomous, allowing you to tackle long-duration operations.
The engineer company Espaa be the first to manufacture this type of robots
The company IT company has applied its experience in control systems for precision actuaciny to develop this product into your System Practitioners Online surveys. The health license issued by the Agency Espaola Medicines and Health Products, is the first granted by this body for a robot of these Features. With it the company will manufacture and market the Robot to Aid in Surgeries Laparoscpica, first manufactured in spain.
As a next step in the marketing of this robot SENER, as exclusive licensee of the patent system espaola attendance robotics invasive cirugamnimamente capable of positioning an instrument in response to quirrgico AYMENT ORDERS fijacina a surgeon without the operating table or after calibracin insertion point, has requested the International Extension of the patent within the European Community, Norteamrica and Asia.
About SENER Engineering and Systems, SA
SENER is an engineering company, Consulting & integration of systems that now gives it an international reference in the ares of Aerospace Engineering, Civil and Architecture, Engineering Processes and Naval Energay . It has a staff of 2,000 ms facturacin employees and more than 350 million. It currently has offices in Madrid, Barcelona, Bilbao, Valencia, Seville, Algiers, Buenos Aires, Lisbon, Mxico DF, Okayama (Japn), San Francisco and Warsaw. Ingenieray SENER SENER Systems is part of Group Engineering, one of the largest engineering groups spaniards, with 4,500 ms and a facturacin exceeding 753 million euros.
spaa begins in a pioneering study that may change the diagnostic and monitoring of hypertensive patients.
EVOLVE study ms have 4,000 patients and aims to demonstrate that new systems of the pressure monitorizacin pressure, MAP and AMPA, improve prediccin of cardiovascular complications and, consequently, may contribute to the reduction of morbidity and mortality in hypertensive patients.
hypertensin The estimated pressure and its consequences are the leading cause of mortality in Espaay, despite this, experts believe that their control is an "inadequate".
One in three adults suffer hypertensin spaniards pressure.
Reported CARDIORISC study, which evaluated 100,000 patients leads to arterial hypertensin Espaa, 50% of treated hypertensives is not well controlled your blood press on.
in addition, this study reveals that conventional medicine is overdiagnosis about 30% of patients.
Arranca en Espaa clinician an ambitious study that may significantly improve the management of blood on our pas hypertensin. Under the name of EVOLVE and an estimated participation of 4,000 ms prediabticos patients and diabetics, the Society of hypertensin Espaola Espaola-League for the Fight Against Blood hypertensin (SEH-LELHA), together with the association so the prevention of cardiovascular risk (PRECAN) and ulcer, intends to see that the new systems of blood monitorizacin of the pressure, MAP (monitorizacin ambulatory blood pressure of the pressure for 24 hours) and AMPA (self medicate pressure of the pressure) are tcnico ms accurate in the diagnostic and monitoring of patients and therefore may contribute in the reduction of morbidity and mortality in hypertensive patients. An advance of great impact if we consider that one in three adults has hypertensin Espaa.
The EVOLVE study is the first step toward a major in evolucin hypertensin management, said Dr. Luis Miguel Ruilope chief hypertensin Unit of Hospital 12 de Octubre de Madrid and member of the Sociedad-Liga hypertensin Espaola of Espaola to Combat hypertensin Arterial (SEH-LELHA) for the submission of this work was held today within the framework of the 14th meeting of the SEH-LELHA. This is a RESEARCH that will offer a considerable improvement for many patients so far diagnosed or over-medicated at risk of suffering a heart attack, stroke, cardiac and renal failure, and premature death. Being a world reference as it is the first study to be conducted including the MAP and AMPA as systems for monitoring blood hypertensin has aadido Dr. Julin Segura, Specialist Unit of hypertensin the Hospital 12 de Octubre.
The tcnico of diagnostics and monitoring in hypertensive patients is the same for many DCAD. Therefore urges the implantacin of a system that reliably detected for ms real tension value and therefore help the physician to better control hypertensin, said Dr. Pedro Aranda, president of the SEH-LELHA.
The EVOLVE study is the result of the findings of the CARDIORISC project, an initiative undertaken by the SEH nica-ao LELHA in 2004 and has been installing 1,200 ms ambulatory MAP in all Espaa and assess nearly 100,000 people with hypertension with this technique. The clinician anlisis-epidemiolgico of the measures taken in these patients indicates that the control of the pressure reaches 50% pressure using ABPM, compared to 25% is achieved with the system of medici No conventional explains Dr. Aranda.
This difference is due to the fact that the conventional medical system pressure of the pressure, many patients experience changes in their numbers motivated by nervousness that makes them take of the pressure the blood in your query , which is known to Sndrome white coat. The MAP, however, to take The pressure at home and every 20 minutes during 24 hours, eliminates this effect, and in addition, provides information on nocturnal blood The pressure, variable which is related very closely with the sighting of cardiovascular events.
About EVOLVE study
This is an observational study that includes annual monitoring for 4 years, and who have an estimated sample of 4041 patients and diabetics prediabticos.
The main objective is to evaluate the value of the pressure Prognosis blood, determined by different measurement tcnico (PA clinician, AMPA and MAP), the incidence of cardiovascular events in hypertensive patients with diabetes Type 2 or prediabticos.
Having the participation of special schools in Occupational Medicine, Primary centers and units Caution hypertensin hospital.
The results of this study are called to lay the groundwork for the application in the experience Training of health surveillance information that facilitates the MAP. Supondrn results that the establishment of the MAP as indispensable in the diagnosis and monitoring of hypertension. It is, therefore, one that aims RESEARCH final response to the urgent need to improve the approach of HBP.
CARDIORISC reaches 100,000 patient-controlled MAP
Consolidndose as follows CARDIORISC largest database of MAP worldwide this month after achieving the 100,000 patients evaluated monitorizacin system of the pressure ambulatory blood 24 hours.
CARDIORISC continuous growth recorded since its inception in 2004, shows its consolidaciny as it reaffirms the largest database of maps of all Europe. CARDIORISC platform, driven by SEH-LELHA in liaison with ulcer, a laboratory that has established itself as the center and engine of knowledge about cardiovascular risk, plans to continue this upward trend, for which last move by introducing new tcnico diagnosis that improve the cardiovascular risk integral Benchmarks.
hypertensin The estimated pressure and its consequences are the leading cause of mortality in Espaay, despite this, experts believe that their control is an "inadequate".
One in three adults suffer hypertensin spaniards pressure.
Reported CARDIORISC study, which evaluated 100,000 patients leads to arterial hypertensin Espaa, 50% of treated hypertensives is not well controlled your blood press on.
in addition, this study reveals that conventional medicine is overdiagnosis about 30% of patients.
Arranca en Espaa clinician an ambitious study that may significantly improve the management of blood on our pas hypertensin. Under the name of EVOLVE and an estimated participation of 4,000 ms prediabticos patients and diabetics, the Society of hypertensin Espaola Espaola-League for the Fight Against Blood hypertensin (SEH-LELHA), together with the association so the prevention of cardiovascular risk (PRECAN) and ulcer, intends to see that the new systems of blood monitorizacin of the pressure, MAP (monitorizacin ambulatory blood pressure of the pressure for 24 hours) and AMPA (self medicate pressure of the pressure) are tcnico ms accurate in the diagnostic and monitoring of patients and therefore may contribute in the reduction of morbidity and mortality in hypertensive patients. An advance of great impact if we consider that one in three adults has hypertensin Espaa.
The EVOLVE study is the first step toward a major in evolucin hypertensin management, said Dr. Luis Miguel Ruilope chief hypertensin Unit of Hospital 12 de Octubre de Madrid and member of the Sociedad-Liga hypertensin Espaola of Espaola to Combat hypertensin Arterial (SEH-LELHA) for the submission of this work was held today within the framework of the 14th meeting of the SEH-LELHA. This is a RESEARCH that will offer a considerable improvement for many patients so far diagnosed or over-medicated at risk of suffering a heart attack, stroke, cardiac and renal failure, and premature death. Being a world reference as it is the first study to be conducted including the MAP and AMPA as systems for monitoring blood hypertensin has aadido Dr. Julin Segura, Specialist Unit of hypertensin the Hospital 12 de Octubre.
The tcnico of diagnostics and monitoring in hypertensive patients is the same for many DCAD. Therefore urges the implantacin of a system that reliably detected for ms real tension value and therefore help the physician to better control hypertensin, said Dr. Pedro Aranda, president of the SEH-LELHA.
The EVOLVE study is the result of the findings of the CARDIORISC project, an initiative undertaken by the SEH nica-ao LELHA in 2004 and has been installing 1,200 ms ambulatory MAP in all Espaa and assess nearly 100,000 people with hypertension with this technique. The clinician anlisis-epidemiolgico of the measures taken in these patients indicates that the control of the pressure reaches 50% pressure using ABPM, compared to 25% is achieved with the system of medici No conventional explains Dr. Aranda.
This difference is due to the fact that the conventional medical system pressure of the pressure, many patients experience changes in their numbers motivated by nervousness that makes them take of the pressure the blood in your query , which is known to Sndrome white coat. The MAP, however, to take The pressure at home and every 20 minutes during 24 hours, eliminates this effect, and in addition, provides information on nocturnal blood The pressure, variable which is related very closely with the sighting of cardiovascular events.
About EVOLVE study
This is an observational study that includes annual monitoring for 4 years, and who have an estimated sample of 4041 patients and diabetics prediabticos.
The main objective is to evaluate the value of the pressure Prognosis blood, determined by different measurement tcnico (PA clinician, AMPA and MAP), the incidence of cardiovascular events in hypertensive patients with diabetes Type 2 or prediabticos.
Having the participation of special schools in Occupational Medicine, Primary centers and units Caution hypertensin hospital.
The results of this study are called to lay the groundwork for the application in the experience Training of health surveillance information that facilitates the MAP. Supondrn results that the establishment of the MAP as indispensable in the diagnosis and monitoring of hypertension. It is, therefore, one that aims RESEARCH final response to the urgent need to improve the approach of HBP.
CARDIORISC reaches 100,000 patient-controlled MAP
Consolidndose as follows CARDIORISC largest database of MAP worldwide this month after achieving the 100,000 patients evaluated monitorizacin system of the pressure ambulatory blood 24 hours.
CARDIORISC continuous growth recorded since its inception in 2004, shows its consolidaciny as it reaffirms the largest database of maps of all Europe. CARDIORISC platform, driven by SEH-LELHA in liaison with ulcer, a laboratory that has established itself as the center and engine of knowledge about cardiovascular risk, plans to continue this upward trend, for which last move by introducing new tcnico diagnosis that improve the cardiovascular risk integral Benchmarks.
SESPAS Declaration of the XIII Congress held in Seville.
The XIII Congress of the Society Espaola administracinė of public health and Health (SESPAS), which under the banner of Times for PUBLIC HEALTH was held in Seville from 3 to 6 March 2009 and the we have assisted some 1,300 experts and professionals in different fields of health openly about all Espaa, remember the following statement:
In the world we live in, where the determinants of health are increasingly global ms, we lack sufficient effective mechanisms of protection in the field worldwide. Urge for establishing, as such have the appropriate international regulatory procedures. We ask that the World Bank, International Monetary Fund, the International Labor organization and the World Trade organization, taking into account the health of poblacina when making their decisions. Arrangements should reform and strengthen multilateral agencies responsible for health-Specific, as the World Health organization.
Limited health inequalities and social development of public health measures can reduce them. Investing in Health, educaciny development of women, for example, one way to improve the health of all people, since they are mainly affected by the majority of social determinants such as poverty, precarious discriminacin employment and the sharing of power.
Climtico change is a real threat to the health of humanity, especially for people and vulnerable ms passes, so it requires an immediate response. We demand the Government of Spain, European governments and Autonmicos Local Authorities effective actions to reduce emissions of greenhouse gases in compliance with the Kyoto Protocol and adopting new international agreements in the same direction. These actions must be aimed at changing the system energtico and transport, or development of renewable energies and sustainable mobility, and no slo permitirn reduce CO2 emissions level but also No atmosfricos many other pollutants that now have significant impacts on our cities. We demand of enterprises and held in public and private entities responsible action to reduce their own emissions, and call the ciudadanaa participate responsibly in this collective effort. En la medida en que, adem s, son necesarias medidas de adaptaci n al cambio clim tico que ya se est produciendo, la salud deber a estar en el centro de las pol ticas nacionales de adaptaci n as in programs of cooperation with the countries vulnerable ms.
In the recent years has developed a process uncontrolled urbaniza without an adequate territorial ordenacin present and future needs of people. As the healthy city let alone anyone else has been completely absent from the process developed in the ltimos urbansticos years. We demand much of those responsible for the incorporacin PUBLIC health value in planificacin estratgica future urban cities and towns.
Sistmica The Economic and global crisis we suffer is a significant impact on poblacin, ms brutal in the excluded and with fewer resources. We require the strengthening of social policies that reduce the negative impact on the affected poblacinms. The current crisis has its causes and responsible so you should not persist in growth patterns and predators and unsustainable development. The crisis can be an opportunity if we learn the lecciny act accordingly, changing things. Not that there is another world possible, is that right now is imperative.
We call the attention on the growing medicalizacin of daily life due to the role the pharmaceutical industry and medical technologists, but Also health administrations, professional and health services. The growth of health costs, partly due to demand, medicalizaciny Also depends on the exponential growth of sophisticated technological and drugs of last generation that, in most cases, provide low added value. Preocupacin particular raises the magnitude reached by the adverse effects of medical attention, which have become a real problem of public health.
It is necessary therefore to undertake major changes. First, change the rules in relations between the administracinė Sanitary and health professionals (and their institutions and associations) on one side and industry on the other.
Second, redefine the relationships between all these actors and the society itself, especially in the necessary participation in making decisions about new services and incorporacin health technologists to avoid populist decisions on the enlargements No portfolio of preventive services (without an independent process of evaluation will deliberate upon their impact and opportunity costs), and prevent or at least hinder the Propagation of wrongdoing beliefs and false expectations about the power of health services to prevent any risk or to treat any life event.
We must refocus our health system towards health or development and community participation, strengthening public health. In that sense, must rethink the coordi relaciny between different levels of care and public health, especially those of primary attention, as to improve the coordination between the National Health System and the Social Security. Assuming responsibility for our part, we propose an alliance between estratgica citizens' associations, professional and Scientific and health systems that could exploit the crisis to effectively reorient health policies to the needs of poblacin, reducing this medicalizaciny thus iatrogenic.
In our European natural Pblico Health occupies a marginal place in the agendas POLICIES-institutional and intersectoral approach to health determinants personal portfolio has a strong presence. We therefore need to strengthen our relationship with the European Public Health Association (EUPHA) and, together, claim the European institutions and governments with greater commitment and strategy PUBLIC HEALTH Health in All POLICIES .
For last of them, and on the basis of experience gained in the years ltimos where errors estn Also, we strongly support reform movements and of public health Actualizacin initiated in several communities Autnomas, as the commitment of the Ministry of Health of a new law promoting public health. Actualizacin reform initiatives and to be carried out in a transparent and participatory, with the professionals, but ciudadanay Also with other sectors and social actors. The participation of society, with an articulacin difficulties involved, remains an unresolved between us, but we can no longer for people but with them, recognizing the right of cities legtimo aa participate in making decisions affecting their health.
We live in times of crisis and uncertainty, but the crisis is threatening ms of not wanting to fight to overcome it. We put our knowledge and our abilities to service changes and changes needed to make all people equal opportunity, can lead a healthy ms.
These are times for PUBLIC HEALTH!
In the world we live in, where the determinants of health are increasingly global ms, we lack sufficient effective mechanisms of protection in the field worldwide. Urge for establishing, as such have the appropriate international regulatory procedures. We ask that the World Bank, International Monetary Fund, the International Labor organization and the World Trade organization, taking into account the health of poblacina when making their decisions. Arrangements should reform and strengthen multilateral agencies responsible for health-Specific, as the World Health organization.
Limited health inequalities and social development of public health measures can reduce them. Investing in Health, educaciny development of women, for example, one way to improve the health of all people, since they are mainly affected by the majority of social determinants such as poverty, precarious discriminacin employment and the sharing of power.
Climtico change is a real threat to the health of humanity, especially for people and vulnerable ms passes, so it requires an immediate response. We demand the Government of Spain, European governments and Autonmicos Local Authorities effective actions to reduce emissions of greenhouse gases in compliance with the Kyoto Protocol and adopting new international agreements in the same direction. These actions must be aimed at changing the system energtico and transport, or development of renewable energies and sustainable mobility, and no slo permitirn reduce CO2 emissions level but also No atmosfricos many other pollutants that now have significant impacts on our cities. We demand of enterprises and held in public and private entities responsible action to reduce their own emissions, and call the ciudadanaa participate responsibly in this collective effort. En la medida en que, adem s, son necesarias medidas de adaptaci n al cambio clim tico que ya se est produciendo, la salud deber a estar en el centro de las pol ticas nacionales de adaptaci n as in programs of cooperation with the countries vulnerable ms.
In the recent years has developed a process uncontrolled urbaniza without an adequate territorial ordenacin present and future needs of people. As the healthy city let alone anyone else has been completely absent from the process developed in the ltimos urbansticos years. We demand much of those responsible for the incorporacin PUBLIC health value in planificacin estratgica future urban cities and towns.
Sistmica The Economic and global crisis we suffer is a significant impact on poblacin, ms brutal in the excluded and with fewer resources. We require the strengthening of social policies that reduce the negative impact on the affected poblacinms. The current crisis has its causes and responsible so you should not persist in growth patterns and predators and unsustainable development. The crisis can be an opportunity if we learn the lecciny act accordingly, changing things. Not that there is another world possible, is that right now is imperative.
We call the attention on the growing medicalizacin of daily life due to the role the pharmaceutical industry and medical technologists, but Also health administrations, professional and health services. The growth of health costs, partly due to demand, medicalizaciny Also depends on the exponential growth of sophisticated technological and drugs of last generation that, in most cases, provide low added value. Preocupacin particular raises the magnitude reached by the adverse effects of medical attention, which have become a real problem of public health.
It is necessary therefore to undertake major changes. First, change the rules in relations between the administracinė Sanitary and health professionals (and their institutions and associations) on one side and industry on the other.
Second, redefine the relationships between all these actors and the society itself, especially in the necessary participation in making decisions about new services and incorporacin health technologists to avoid populist decisions on the enlargements No portfolio of preventive services (without an independent process of evaluation will deliberate upon their impact and opportunity costs), and prevent or at least hinder the Propagation of wrongdoing beliefs and false expectations about the power of health services to prevent any risk or to treat any life event.
We must refocus our health system towards health or development and community participation, strengthening public health. In that sense, must rethink the coordi relaciny between different levels of care and public health, especially those of primary attention, as to improve the coordination between the National Health System and the Social Security. Assuming responsibility for our part, we propose an alliance between estratgica citizens' associations, professional and Scientific and health systems that could exploit the crisis to effectively reorient health policies to the needs of poblacin, reducing this medicalizaciny thus iatrogenic.
In our European natural Pblico Health occupies a marginal place in the agendas POLICIES-institutional and intersectoral approach to health determinants personal portfolio has a strong presence. We therefore need to strengthen our relationship with the European Public Health Association (EUPHA) and, together, claim the European institutions and governments with greater commitment and strategy PUBLIC HEALTH Health in All POLICIES .
For last of them, and on the basis of experience gained in the years ltimos where errors estn Also, we strongly support reform movements and of public health Actualizacin initiated in several communities Autnomas, as the commitment of the Ministry of Health of a new law promoting public health. Actualizacin reform initiatives and to be carried out in a transparent and participatory, with the professionals, but ciudadanay Also with other sectors and social actors. The participation of society, with an articulacin difficulties involved, remains an unresolved between us, but we can no longer for people but with them, recognizing the right of cities legtimo aa participate in making decisions affecting their health.
We live in times of crisis and uncertainty, but the crisis is threatening ms of not wanting to fight to overcome it. We put our knowledge and our abilities to service changes and changes needed to make all people equal opportunity, can lead a healthy ms.
These are times for PUBLIC HEALTH!
Biomrieux test launches innovative molecular diagnostics for the prevention of cncer of crvix.
bioMrieux, lder worldwide in the field of in vitro diagnostics, has launched NucliSENS EasyQ HPV, a molecular diagnostics test for human papillomavirus deteccin used in the prevention of c cervical cancer.
The neck cncer uterus is one of the leading causes of death among women in the development passes you, and in addition, is the second type of common cncer ms worldwide. Every year 250,000 ms muertes.1 causes human papillomavirus, or HPV, is responsible for 99.7% of cases of uterino.2 neck cncer Numerous investigations have demonstrated that genotypes 16 and 18 cause about 70% of uterus neck cnceres HPV-induced wide world.3
In most cases, infection by HPV is transient. However, in 20% of women may have a persistent and cause injury carcter cervical (neck of the uterus). Of 1 to 10% of these lesions may develop into a cancer of crvix. It is therefore very important to identify clearly and early the infeccin in women who are at high risk of developing this type of cancer.
The tcnico of molecular diagnostics for HPV deteccin are used in screening patients with suspected precancerous cervical lesions.
These methods, described, along with anlisis citolgicos (crvico-vaginal smear), help determine a qu women, those with abnormal results citolgicos (ASCUS *), they must guide immediately to biopsy and tratamiento.4
The majority of the current HPV molecular tests allow deteccin-DNA-virus genome in cervical cells;. However, the positive test result indicates a infeccin only HPV, whether transient or persistent. These tests do not eval oncognica virus activity, ie its potential to cause cancer.
It is known that after the integration of the viral genome into the genome of the cells cervical Husped occurs expresin PROTEIN oncognicas the persistent viral E6 and E7.
This involves expresin abnormal modificacin cell cycle, leading to an increased cellular proliferacin, starting as a process of malignizacin from the cervix. Indeed, this seal represents an early marker of cncer.5
Reported by various publications, 6,7,8 of the deteccin The expression of oncogenes E6/E7 (mRNA level) est closely linked to the presence of high grade precancerous lesions in women who have a type cytology ASCUS / LSIL **. That is why this type of experiment is ms-Specific, and has great value in health surveillance methods, described comparacin with deteccin based on DNA. As the results immediately orient patients to undergo a colposcopy, significantly decreasing the number of invasive examinations Intil (biopsies, other colposcopy) .9
* ASCUS: squamous cells; atpicas of undetermined significance
** LSIL: squamous intraepithelial lesions of low grade
EasyQ NucliSENS HPV tests are based on an innovative concept that detects The expression of risk factors oncognicos E6 and E7 in 5 ms frequent HPV types for this type of Cancer (HPV 16, 18, 31, 33 and 45). Thanks to this-Specific diagnostics, the new method offers professionals a valuable health surveillance test, which can improve significantly the attention of patients.
Recognizing the value of the evidence clinician for deteccin of E6/E7 mRNA rpidamente expands its proof is in incorporacin recent Danish national recommendations for the diagnostics of neck cncer of uterus.
References:
1. WHO website referred pages / NCCC websites
2. Walboomers, et al., Human papillomavirus is a necessary cause of invasive cervical cancer worldwide.J. Pathol. 1999, 189: 12-19
3. Kahn et al., The elevated 10-year risk of high risk of cervical cancer in women with HPV type 16 or 18. J. Nat Cancer Inst 2005, Vol 97, n 14
4. Wright TC, Schiffman M, Solomon D et al., Interim guidance for the use of human papillomavirus DNA testing as an adjunct to cervical cytology for screening. Obstet Gynecol. 2004; 103:304-309
5. Zur Hausen et al. Papillomavirus and cancer: from basic studies to clinical application. Nat Rev Cancer 2002, 2: 342-50.
6. Lie et al., DNA-versus RNA-based methods for HPV detection in cervical neoplasia. Gynec. Onc. 2005, 97: 908-915
7. Molden et al., Comparison of HPV mRNA and DNA detection: a cross-sectional study of 4136 women> 30 years of age with a 2-years follow-up of high grade squamous intraepithelial lesion. Int J. Cancer 2005; 114: 973-976
8. Cuschieri et al., HPV type specific DNA and RNA persistence-implications for cervical disease progression and monitoring. J. Virol.2004 Med, 73: 65-70
9. Molden et al., Predicting CIN2 + when detecting HPV mRNA and DNA by PreTect HPV-Proofer and consensus PCR: a 2-year Follow-up of women with ASCUS or LSIL Pap smear. Int J. Cancer 2005; 114: 973-976
10. Screening for Cervical Cancer. Sundhedsstyrelsen, Denmark, 2007
About bioMrieux, lder worldwide in the field of in vitro diagnostics for 45 years, bioMrieux est present in 150 ms travs passes of 39 subsidiaries and a extensive network of distributors. In 2007, the volume totaled bioMrieux facturacin of 1 063 million, of which 84% corresponds to its international activity.
bioMrieux offers diagnostics solutions (reagents, instruments and software) which determine the source of a disease or contaminacin to improve patient health and ensure consumer safety. BioMrieux products are used in the diagnostics of infectious diseases and provide health surveillance valuable results for cardiovascular emergencies and the diagnostics and monitoring of cancer. Also used for deteccin microorganisms in agri-food products and cosmetics farmacuticos.
bioMrieux is a company listed on NYSE Euronext Paris. (Cdigo: BIM - Cdigo ISIN: FR0010096479).
The neck cncer uterus is one of the leading causes of death among women in the development passes you, and in addition, is the second type of common cncer ms worldwide. Every year 250,000 ms muertes.1 causes human papillomavirus, or HPV, is responsible for 99.7% of cases of uterino.2 neck cncer Numerous investigations have demonstrated that genotypes 16 and 18 cause about 70% of uterus neck cnceres HPV-induced wide world.3
In most cases, infection by HPV is transient. However, in 20% of women may have a persistent and cause injury carcter cervical (neck of the uterus). Of 1 to 10% of these lesions may develop into a cancer of crvix. It is therefore very important to identify clearly and early the infeccin in women who are at high risk of developing this type of cancer.
The tcnico of molecular diagnostics for HPV deteccin are used in screening patients with suspected precancerous cervical lesions.
These methods, described, along with anlisis citolgicos (crvico-vaginal smear), help determine a qu women, those with abnormal results citolgicos (ASCUS *), they must guide immediately to biopsy and tratamiento.4
The majority of the current HPV molecular tests allow deteccin-DNA-virus genome in cervical cells;. However, the positive test result indicates a infeccin only HPV, whether transient or persistent. These tests do not eval oncognica virus activity, ie its potential to cause cancer.
It is known that after the integration of the viral genome into the genome of the cells cervical Husped occurs expresin PROTEIN oncognicas the persistent viral E6 and E7.
This involves expresin abnormal modificacin cell cycle, leading to an increased cellular proliferacin, starting as a process of malignizacin from the cervix. Indeed, this seal represents an early marker of cncer.5
Reported by various publications, 6,7,8 of the deteccin The expression of oncogenes E6/E7 (mRNA level) est closely linked to the presence of high grade precancerous lesions in women who have a type cytology ASCUS / LSIL **. That is why this type of experiment is ms-Specific, and has great value in health surveillance methods, described comparacin with deteccin based on DNA. As the results immediately orient patients to undergo a colposcopy, significantly decreasing the number of invasive examinations Intil (biopsies, other colposcopy) .9
* ASCUS: squamous cells; atpicas of undetermined significance
** LSIL: squamous intraepithelial lesions of low grade
EasyQ NucliSENS HPV tests are based on an innovative concept that detects The expression of risk factors oncognicos E6 and E7 in 5 ms frequent HPV types for this type of Cancer (HPV 16, 18, 31, 33 and 45). Thanks to this-Specific diagnostics, the new method offers professionals a valuable health surveillance test, which can improve significantly the attention of patients.
Recognizing the value of the evidence clinician for deteccin of E6/E7 mRNA rpidamente expands its proof is in incorporacin recent Danish national recommendations for the diagnostics of neck cncer of uterus.
References:
1. WHO website referred pages / NCCC websites
2. Walboomers, et al., Human papillomavirus is a necessary cause of invasive cervical cancer worldwide.J. Pathol. 1999, 189: 12-19
3. Kahn et al., The elevated 10-year risk of high risk of cervical cancer in women with HPV type 16 or 18. J. Nat Cancer Inst 2005, Vol 97, n 14
4. Wright TC, Schiffman M, Solomon D et al., Interim guidance for the use of human papillomavirus DNA testing as an adjunct to cervical cytology for screening. Obstet Gynecol. 2004; 103:304-309
5. Zur Hausen et al. Papillomavirus and cancer: from basic studies to clinical application. Nat Rev Cancer 2002, 2: 342-50.
6. Lie et al., DNA-versus RNA-based methods for HPV detection in cervical neoplasia. Gynec. Onc. 2005, 97: 908-915
7. Molden et al., Comparison of HPV mRNA and DNA detection: a cross-sectional study of 4136 women> 30 years of age with a 2-years follow-up of high grade squamous intraepithelial lesion. Int J. Cancer 2005; 114: 973-976
8. Cuschieri et al., HPV type specific DNA and RNA persistence-implications for cervical disease progression and monitoring. J. Virol.2004 Med, 73: 65-70
9. Molden et al., Predicting CIN2 + when detecting HPV mRNA and DNA by PreTect HPV-Proofer and consensus PCR: a 2-year Follow-up of women with ASCUS or LSIL Pap smear. Int J. Cancer 2005; 114: 973-976
10. Screening for Cervical Cancer. Sundhedsstyrelsen, Denmark, 2007
About bioMrieux, lder worldwide in the field of in vitro diagnostics for 45 years, bioMrieux est present in 150 ms travs passes of 39 subsidiaries and a extensive network of distributors. In 2007, the volume totaled bioMrieux facturacin of 1 063 million, of which 84% corresponds to its international activity.
bioMrieux offers diagnostics solutions (reagents, instruments and software) which determine the source of a disease or contaminacin to improve patient health and ensure consumer safety. BioMrieux products are used in the diagnostics of infectious diseases and provide health surveillance valuable results for cardiovascular emergencies and the diagnostics and monitoring of cancer. Also used for deteccin microorganisms in agri-food products and cosmetics farmacuticos.
bioMrieux is a company listed on NYSE Euronext Paris. (Cdigo: BIM - Cdigo ISIN: FR0010096479).
Tuesday, February 17, 2009
cosmetic surgery age 16
Istanbul University (IU) Cerrahpasa Medical Faculty Department of Plastic Reconstructive and Aesthetic Surgery, Specialist Professor. Dr. Oğuz Çetinkale, excellent or better for an image requested cosmetic surgery, the long years of hard working conditions of the traces of fatigue, caused by a bad case of the spirit reflected in the face and physics in order to correct the statement had been demanded.
"Applying an important part of the patient, or other similar reasons for a new beginning is coming. Problem, replete with errors, considered to be unwanted or irritating many people who want to get rid of the past, known to change expression known to have plastic surgery is like. "
Especially from people who want a divorce, and serve with the aesthetics of the 80 percent rate of change in identity that indicates Çetinkale, this surgery is done without a court order not stressed.
Çetinkale, who go for plastic surgery to make sure of that by taking years to fall to 16, said:
"Aesthetic surgery is done for 16-17 years in the youth, families began to contact the clinics. Plastic surgeon as an emergency before the age of 18, except we do not recommend plastic surgery to be done. However, some young people are obsessed with plastic surgery to do so insistent on this issue are for. In this case, families with children 18 years of age to complete the University exams are recommended to set the conditions get better scores. "
Expressed to this proposal, families who look hot Çetinkale, "So the child's heart is unbroken and has encouraged young people to university exams," he said.
Most are applying for aesthetic nose anlatan Çetinkale, "Men women breast growth type correction, the fat girl is fat turn, did not develop breast prosthesis in place and botoks request to apply to us," he spoke.
"Applying an important part of the patient, or other similar reasons for a new beginning is coming. Problem, replete with errors, considered to be unwanted or irritating many people who want to get rid of the past, known to change expression known to have plastic surgery is like. "
Especially from people who want a divorce, and serve with the aesthetics of the 80 percent rate of change in identity that indicates Çetinkale, this surgery is done without a court order not stressed.
Çetinkale, who go for plastic surgery to make sure of that by taking years to fall to 16, said:
"Aesthetic surgery is done for 16-17 years in the youth, families began to contact the clinics. Plastic surgeon as an emergency before the age of 18, except we do not recommend plastic surgery to be done. However, some young people are obsessed with plastic surgery to do so insistent on this issue are for. In this case, families with children 18 years of age to complete the University exams are recommended to set the conditions get better scores. "
Expressed to this proposal, families who look hot Çetinkale, "So the child's heart is unbroken and has encouraged young people to university exams," he said.
Most are applying for aesthetic nose anlatan Çetinkale, "Men women breast growth type correction, the fat girl is fat turn, did not develop breast prosthesis in place and botoks request to apply to us," he spoke.
What is Plastic and Aesthetic Surgery?
Plastic Surgery of physical dysfunction is corrected, accidents, illnesses, congenital defects and disorders of the specific branch of medicine is a decrease investigate.
Plastic forming of the word in ancient Greek, which means the format "plastos derived from the word. Plastic surgery encompasses both cosmetic and reconstructive surgery on.
Aesthetic surgery of face and body shape for the feature and to fix a person's appearance by making good purposes. Reconstructive surgery of the face or body to rebuild, repair or strengthen the physical functions. An accident, illness or congenital deformation of the second degree is minimized. Plastic surgery, aesthetic surgery, a reconstruction of the area where the tissues are damaged or deformed again to revert to the repair process.
History of Aesthetic Plastic Surgery ..
Plastic and aesthetic surgery of the history of BC Up to 600 years based lü. Documents of this period, India remained disconnected as a penalty after being cut to the nose tip describes how the repair. Modern plastic surgery in the 19th yy also began to develop. First known in history of breast reduction surgery in 1669 to start making a real success of surgery in 1900 were the years of lü. Real growth in plastic surgery, especially with the wars 2nd With world war had, in this war, emerging applications and the maintenance of organ loss was well developed. S first wife in 1950 in stretching surgery Liposuction (oil import) methods and procedures to be implemented after the 1960-70 lerden began to develop. Breast surgery began in 1963 in the use of silicone prostheses. Today is a very popular methods used in cosmetic surgery is rapidly developing and diversifying.
Why is important and necessary to be beautiful?
Plastic and aesthetic surgery, is of interest to people that want to be good for the stems. Women or men from other people with good life is always more lucky since birth and can be successful. Fine was born a baby born more than a nurse does not care about the room to see, crying for everyone who deals with him first. In school life, teachers and friends every time he shows more interest and understanding are. This situation will continue in business. Jobs in the candidates with equal conditions for business is always good. Of a Mexican plastic surgeon says, "Beauty is more efficient than the best reference letters. These people rely on their own is too much in human relationships can be more successful. So in short, except for exceptional beauty for success in life is necessarily a requirement. Plastic and aesthetic surgery, the goal of their own people to gain self-confidence and its relationship with the environment to be more successful and happy to help.
Why are cosmetic surgery and who?
People who are satisfied with the appearance of their peace, and social relations more successful in business life, love and marriage can be happy in your life easier. Not satisfied with the appearance, position kendilerince defects as they are applied to us for correction. This complex is defective or think they do or where they are contacting us for work required surgery.
For example, a woman with small breast surgery patients from 1 month after I met someone and got married within 4 months. Here the main influence on the enlargement of her breasts, but the person's own self-confidence increased as a result is more successful in human relationships. Another example of a patient model from my breast and nose surgery improves the job very well is make money and more popular, he said.
Draw the person's self-satisfied with the image is in place. Business and social life is successful. Relations are comfortable. Look in the mirror when no one's face is not worthy, after pregnancy, such as the former wife of the plane or the side that lost elasticity and sag and rind see think of the bad and the environment in its relationship with the arrest and can act incompatible
Aesthetic Surgery is the most appropriate candidates who?
According to statistics, every year, millions of people, to make images more beautiful aesthetic surgery referenced. Some significant changes in size and some are seeking footling corrections.
A long time regarded as the savior of women are only cosmetic surgery today a lot of good results and discover the advantages also attracts the attention of men. For example, men and women show similarities in the nose surgery. Some men want to get rid of the fat. Oils for men breasts, waist and abdomen, while women gathered in the waist, hips, thigh, abdomen and sometimes in hock to accumulate. Laser epilation is more popular way, men think that women have disturb the aesthetic appearance as well as want to get rid of hair.
Many plastic surgery techniques and school preparation for surgery but usually occurs in three stages. One, to prepare yourself psychologically for the surgery. The other is whether or not favorable to the health of your surgery to determine the need for laboratory analysis and research to be done, such as x-ray images. Third you want the plastic surgery specialist your doctor's surgery and the possiblities that this is what will be decided is the most important stage. Here, a plastic surgeon and patient selection as well suited for plastic surgery patients choose the doctors on both sides that adapt to each other is very important.
The most appropriate candidates for cosmetic surgery because of defects can be corrected deformity residents. The person who heard the disturbance outside appearance, correct aesthetic defects after life is starting to look much more fun. Your face or your body "fix" allows you to regain your confidence in yourself. But it also does not guarantee happiness. One day my nose surgery done surgery immediately after a sick lady in bed "Doctor, I ask you guys do not get one now" he said.
Against nearby ...
Undoubtedly, many people want to change after plastic surgery. However, this change resulted from plastic surgery to be understood that the number of not very high.
But men have cosmetic surgery to women than to hide the power. Because women make up marks on the bottom of the operation can easily hide. Aesthetic surgery around us will tell you our decision kalmıştır.Bazıları your surgery will be explained to all the friends, while some others have gizlerler.Ne state secret that the environment, such as what you have plastic surgery to tell you, you have an operation to store the energy expenditure is easier to forget. Nevertheless, the difference is less than your transition period has some ways to make. Most of the proposed road at the same time is to change your style. Thus, changes in your appearance, except for people in your environment, not the surgery, due to changes in your style you will feel. That is, the weight can change the style or color of your hair or you can wear contact lenses instead of glasses.
Who should have an operation.?
If you'd decided to have plastic surgery and aesthetic plastic surgery specialists always have to be examined. This surgeon is a member of the Turkish Association of Plastic surgery and plastic surgery in the branch must have a diploma showing specialize. Interests you in detail all aspects of learning from these experts should be applied and the type of surgical technique is appropriate you should identify with your surgeon, complications and risks that could occur should ask as previously detailed.
Most are doing.
* Nasal congestion in the nose, and beautiful way to troubleshoot ...
* Breast enlargement ...
* Breast reduction and steepen the ...
* In cases where the breast is taken heavens are ...
* Abdominal strain ...
* Liposuction (abdomen, waist, hips, legs, ankle to get fat, etc) ...
* The receipt of oil in the thigh ...
* Get the stream ...
* Kas removal ...
* Eye lids gerilmesi, to get the bag ...
* Face rejuvenescence ...
* Neck lift tickle ...
* Botox and wrinkle correction of ...
* Lips thickening ...
* Face the lines of fat or tissue cocktail injection ...
* Face "peeling" i (paring) ...
* Laser treatment of facial spots in the rural and ...
* Hair sowing ...
* Laser Hair Removal ...
Plastic forming of the word in ancient Greek, which means the format "plastos derived from the word. Plastic surgery encompasses both cosmetic and reconstructive surgery on.
Aesthetic surgery of face and body shape for the feature and to fix a person's appearance by making good purposes. Reconstructive surgery of the face or body to rebuild, repair or strengthen the physical functions. An accident, illness or congenital deformation of the second degree is minimized. Plastic surgery, aesthetic surgery, a reconstruction of the area where the tissues are damaged or deformed again to revert to the repair process.
History of Aesthetic Plastic Surgery ..
Plastic and aesthetic surgery of the history of BC Up to 600 years based lü. Documents of this period, India remained disconnected as a penalty after being cut to the nose tip describes how the repair. Modern plastic surgery in the 19th yy also began to develop. First known in history of breast reduction surgery in 1669 to start making a real success of surgery in 1900 were the years of lü. Real growth in plastic surgery, especially with the wars 2nd With world war had, in this war, emerging applications and the maintenance of organ loss was well developed. S first wife in 1950 in stretching surgery Liposuction (oil import) methods and procedures to be implemented after the 1960-70 lerden began to develop. Breast surgery began in 1963 in the use of silicone prostheses. Today is a very popular methods used in cosmetic surgery is rapidly developing and diversifying.
Why is important and necessary to be beautiful?
Plastic and aesthetic surgery, is of interest to people that want to be good for the stems. Women or men from other people with good life is always more lucky since birth and can be successful. Fine was born a baby born more than a nurse does not care about the room to see, crying for everyone who deals with him first. In school life, teachers and friends every time he shows more interest and understanding are. This situation will continue in business. Jobs in the candidates with equal conditions for business is always good. Of a Mexican plastic surgeon says, "Beauty is more efficient than the best reference letters. These people rely on their own is too much in human relationships can be more successful. So in short, except for exceptional beauty for success in life is necessarily a requirement. Plastic and aesthetic surgery, the goal of their own people to gain self-confidence and its relationship with the environment to be more successful and happy to help.
Why are cosmetic surgery and who?
People who are satisfied with the appearance of their peace, and social relations more successful in business life, love and marriage can be happy in your life easier. Not satisfied with the appearance, position kendilerince defects as they are applied to us for correction. This complex is defective or think they do or where they are contacting us for work required surgery.
For example, a woman with small breast surgery patients from 1 month after I met someone and got married within 4 months. Here the main influence on the enlargement of her breasts, but the person's own self-confidence increased as a result is more successful in human relationships. Another example of a patient model from my breast and nose surgery improves the job very well is make money and more popular, he said.
Draw the person's self-satisfied with the image is in place. Business and social life is successful. Relations are comfortable. Look in the mirror when no one's face is not worthy, after pregnancy, such as the former wife of the plane or the side that lost elasticity and sag and rind see think of the bad and the environment in its relationship with the arrest and can act incompatible
Aesthetic Surgery is the most appropriate candidates who?
According to statistics, every year, millions of people, to make images more beautiful aesthetic surgery referenced. Some significant changes in size and some are seeking footling corrections.
A long time regarded as the savior of women are only cosmetic surgery today a lot of good results and discover the advantages also attracts the attention of men. For example, men and women show similarities in the nose surgery. Some men want to get rid of the fat. Oils for men breasts, waist and abdomen, while women gathered in the waist, hips, thigh, abdomen and sometimes in hock to accumulate. Laser epilation is more popular way, men think that women have disturb the aesthetic appearance as well as want to get rid of hair.
Many plastic surgery techniques and school preparation for surgery but usually occurs in three stages. One, to prepare yourself psychologically for the surgery. The other is whether or not favorable to the health of your surgery to determine the need for laboratory analysis and research to be done, such as x-ray images. Third you want the plastic surgery specialist your doctor's surgery and the possiblities that this is what will be decided is the most important stage. Here, a plastic surgeon and patient selection as well suited for plastic surgery patients choose the doctors on both sides that adapt to each other is very important.
The most appropriate candidates for cosmetic surgery because of defects can be corrected deformity residents. The person who heard the disturbance outside appearance, correct aesthetic defects after life is starting to look much more fun. Your face or your body "fix" allows you to regain your confidence in yourself. But it also does not guarantee happiness. One day my nose surgery done surgery immediately after a sick lady in bed "Doctor, I ask you guys do not get one now" he said.
Against nearby ...
Undoubtedly, many people want to change after plastic surgery. However, this change resulted from plastic surgery to be understood that the number of not very high.
But men have cosmetic surgery to women than to hide the power. Because women make up marks on the bottom of the operation can easily hide. Aesthetic surgery around us will tell you our decision kalmıştır.Bazıları your surgery will be explained to all the friends, while some others have gizlerler.Ne state secret that the environment, such as what you have plastic surgery to tell you, you have an operation to store the energy expenditure is easier to forget. Nevertheless, the difference is less than your transition period has some ways to make. Most of the proposed road at the same time is to change your style. Thus, changes in your appearance, except for people in your environment, not the surgery, due to changes in your style you will feel. That is, the weight can change the style or color of your hair or you can wear contact lenses instead of glasses.
Who should have an operation.?
If you'd decided to have plastic surgery and aesthetic plastic surgery specialists always have to be examined. This surgeon is a member of the Turkish Association of Plastic surgery and plastic surgery in the branch must have a diploma showing specialize. Interests you in detail all aspects of learning from these experts should be applied and the type of surgical technique is appropriate you should identify with your surgeon, complications and risks that could occur should ask as previously detailed.
Most are doing.
* Nasal congestion in the nose, and beautiful way to troubleshoot ...
* Breast enlargement ...
* Breast reduction and steepen the ...
* In cases where the breast is taken heavens are ...
* Abdominal strain ...
* Liposuction (abdomen, waist, hips, legs, ankle to get fat, etc) ...
* The receipt of oil in the thigh ...
* Get the stream ...
* Kas removal ...
* Eye lids gerilmesi, to get the bag ...
* Face rejuvenescence ...
* Neck lift tickle ...
* Botox and wrinkle correction of ...
* Lips thickening ...
* Face the lines of fat or tissue cocktail injection ...
* Face "peeling" i (paring) ...
* Laser treatment of facial spots in the rural and ...
* Hair sowing ...
* Laser Hair Removal ...
Sunday, February 15, 2009
An assisted reproduction technique allows the formation of embryo in the womb, not in the lab.
With this technique there is no surplus embryos.
• It is an alternative for those who claim moral or ethical reasons with in vitro fertilization
20% of the 600,000 couples in our country does not use in vitro fertilization by ethical or moral grounds. Fertilization outside the womb and the fate of surplus embryos to be morally prevent this technique. However, a "version" shorter in vitro fertilization, to allow these couples to have a more natural pregnancy, because the embryo is formed in the uterus of the woman, not in the lab, and no surplus embryos.
The transfer of gametes, is a technique that is about halfway between the artificial insemination and in vitro fertilization. In artificial insemination the sperm are deposited inside the uterus to penetrate the egg and fertile, but it is a technique with limited results, only achieved a 12% success rate per cycle. In the in vitro fertilization (IVF) fertilization is performed in the laboratory, eggs were extracted by puncture of women through the vagina, and fertility of the male sperm in the laboratory. After a few days, the embryos-usually two, are deposited in the womb. Supernumerary embryos is permitted crioconservan in banks for a maximum of 5 years. It is the technique most commonly used by couples (or single women) with the fertility of either male or female or both (obstruction of the fallopian tubes, endometriosis, male infertility, infertility of unknown origin, changes in ovulation, age ...) The average rate of pregnancy with IVF is approximately 45%.
"With the technical transfer of gametes (the female gamete is the ovum and sperm is the male gamete) what we do is extract the eggs and, within hours, transfer them with sperm to the womb, without waiting for have been fertilized. The embryo is formed inside the woman, "says Dr. Dr. Alfonso de la Fuente, with over 15 years of experience in assisted reproductive technologies and director of the Fertility Institute of Madrid, whose team has achieved successfully perform this technique after an upgrade of its methodology.
Dr. Alfonso de la Fuente.
"The steps are the same as an in vitro fertilization, preparing women through stimulation of ovulation. The purpose is to obtain the development of several follicles, inside which are eggs This process is usually monitored by ultrasound vaginal reporting the number and size of developing follicles.
The eggs are extracted through the puncture and aspiration of ovarian follicles, low vision and vaginal ultrasound. This intervention is usually done on an outpatient basis and requires an anesthetic and sedation during a subsequent observation period varies.
Once the eggs are prepared and graded in the laboratory. Select the most suitable sperm. Grown in the laboratory together under favorable conditions, for a few hours and then be able to transfer sperm to the oocyte 3 uterine cavity, is waiting for the fertilization and embryo implantation.
It is a "more natural, with results not so good as in traditional in vitro fertilization, but higher than in artificial insemination, are around 28-29% success. It is also a more economical technique, on 30-35% less than in vitro fertilization, because the laboratory, the most expensive, is much shorter.
"A few years ago we used a similar technique, but instead of transferring gametes to the uterus, were transferred to the fallopian tube, where fertilization normally occurs in the egg and sperm. It was thought that this would encourage pregnancy but was abandoned because it required a more complex surgical procedure for women and the results were not relevant. "
"This says Dr. Alfonso de la Fuente is an alternative for couples unable to have children and do not accept the conditions posed ethical IVF (frozen embryo extracorporeal fertilization) or who have failed in several attempts in vitro fertilization (repeated failure of implantation). "
80% of pregnancies are achieved in the first three cycles
The factors that determine the likelihood of pregnancy are the cause of infertility, age of the patient, the number of ova obtained and the quality of sperm.
"However, we must bear in mind that not all patients who begin treatment achieved follicular development suitable to be subjected to the puncture, and not all who reach this stage can receive transfer of eggs / sperm, since in some cases failed to obtain eggs or sperm do not have the appropriate conditions. "
The European Institute of Fertility is dedicated exclusively to studying and treating disorders related to reproduction. Is headed by Dr. Alfonso de la Fuente, with over 15 years of experience in this field and has been an associate professor at the Autonomous University of Madrid.
C / General Rodrigo, 6 - 28003 Madrid. Tel: 91 543 99 40 - http://www.iefertilidad.com.
• It is an alternative for those who claim moral or ethical reasons with in vitro fertilization
20% of the 600,000 couples in our country does not use in vitro fertilization by ethical or moral grounds. Fertilization outside the womb and the fate of surplus embryos to be morally prevent this technique. However, a "version" shorter in vitro fertilization, to allow these couples to have a more natural pregnancy, because the embryo is formed in the uterus of the woman, not in the lab, and no surplus embryos.
The transfer of gametes, is a technique that is about halfway between the artificial insemination and in vitro fertilization. In artificial insemination the sperm are deposited inside the uterus to penetrate the egg and fertile, but it is a technique with limited results, only achieved a 12% success rate per cycle. In the in vitro fertilization (IVF) fertilization is performed in the laboratory, eggs were extracted by puncture of women through the vagina, and fertility of the male sperm in the laboratory. After a few days, the embryos-usually two, are deposited in the womb. Supernumerary embryos is permitted crioconservan in banks for a maximum of 5 years. It is the technique most commonly used by couples (or single women) with the fertility of either male or female or both (obstruction of the fallopian tubes, endometriosis, male infertility, infertility of unknown origin, changes in ovulation, age ...) The average rate of pregnancy with IVF is approximately 45%.
"With the technical transfer of gametes (the female gamete is the ovum and sperm is the male gamete) what we do is extract the eggs and, within hours, transfer them with sperm to the womb, without waiting for have been fertilized. The embryo is formed inside the woman, "says Dr. Dr. Alfonso de la Fuente, with over 15 years of experience in assisted reproductive technologies and director of the Fertility Institute of Madrid, whose team has achieved successfully perform this technique after an upgrade of its methodology.
Dr. Alfonso de la Fuente.
"The steps are the same as an in vitro fertilization, preparing women through stimulation of ovulation. The purpose is to obtain the development of several follicles, inside which are eggs This process is usually monitored by ultrasound vaginal reporting the number and size of developing follicles.
The eggs are extracted through the puncture and aspiration of ovarian follicles, low vision and vaginal ultrasound. This intervention is usually done on an outpatient basis and requires an anesthetic and sedation during a subsequent observation period varies.
Once the eggs are prepared and graded in the laboratory. Select the most suitable sperm. Grown in the laboratory together under favorable conditions, for a few hours and then be able to transfer sperm to the oocyte 3 uterine cavity, is waiting for the fertilization and embryo implantation.
It is a "more natural, with results not so good as in traditional in vitro fertilization, but higher than in artificial insemination, are around 28-29% success. It is also a more economical technique, on 30-35% less than in vitro fertilization, because the laboratory, the most expensive, is much shorter.
"A few years ago we used a similar technique, but instead of transferring gametes to the uterus, were transferred to the fallopian tube, where fertilization normally occurs in the egg and sperm. It was thought that this would encourage pregnancy but was abandoned because it required a more complex surgical procedure for women and the results were not relevant. "
"This says Dr. Alfonso de la Fuente is an alternative for couples unable to have children and do not accept the conditions posed ethical IVF (frozen embryo extracorporeal fertilization) or who have failed in several attempts in vitro fertilization (repeated failure of implantation). "
80% of pregnancies are achieved in the first three cycles
The factors that determine the likelihood of pregnancy are the cause of infertility, age of the patient, the number of ova obtained and the quality of sperm.
"However, we must bear in mind that not all patients who begin treatment achieved follicular development suitable to be subjected to the puncture, and not all who reach this stage can receive transfer of eggs / sperm, since in some cases failed to obtain eggs or sperm do not have the appropriate conditions. "
The European Institute of Fertility is dedicated exclusively to studying and treating disorders related to reproduction. Is headed by Dr. Alfonso de la Fuente, with over 15 years of experience in this field and has been an associate professor at the Autonomous University of Madrid.
C / General Rodrigo, 6 - 28003 Madrid. Tel: 91 543 99 40 - http://www.iefertilidad.com.
Hospital de Sant Boi implant with the HP Electronic Medical Record.
Hospital de Sant Boi implant with the HP Electronic Medical Record.
The project involves a total investment of more than 800,000 euros
Hospital de Sant Boi, part of the Hospitaller Order of St John of God, he has more than 800,000 euros to the implementation of electronic patient record, with the help of HP. This project, which involves deploying HP-HCIS, the integrated information system for the health sector of Hewlett-Packard, and consolidate hospital andalusia andalusia andalusia owned group as a reference in the field of ICT sector.
According to Dr. Ramón Rosa, Managing Director of the Hospital de Sant Boi, "This project represents a transformation in the current management of the center and meets the need of providing quality care to the population. On the other hand, provides a flexibility in the care process, ensuring maximum security and confidentiality of information. This project, which encompasses the whole organization, is the result of commitment to the demands of today's society. Not only do we want to improve the structure, but we seek professional excellence to provide the reference population. "
A project in two phases
The introduction of HP-HCIS assumed that the health center to become one of the most advanced from a technological point of view, which would have identified two distinct phases. A first "administrative" to be held in nine months, which will carry out the deployment of administrative tools that are responsible for all efforts that affect the patients. Among them, the modules of hospital admissions and emergency summons, filing of medical records or management of waiting lists and surgical block.
Once this process is beginning a second phase "clinic", which will put everything on the history of the patients, the Clinical Work Station, Applications Manager, Protocolos Care Nursing Clinics and different trajectories care management tools. The entire project will be completed before the transfer from hospital to a new and modern facilities being built, and double its current capacity.
"Increasingly, health centers that are bidding for the HP-HCIS time to implement the electronic patient record," says Enrique Solbes, Director of HP Consulting & Integration for Spain and Portugal. "Undoubtedly, this agreement with the Hospital de Sant Boi is going to allow this center to become consolidated as one of the most advanced from a technological point of view, and that HP is still contributing to the continuous improvement of the Spanish health system."
More than 20 years of experience in the health sector
HP Spanish has about 20 years of experience in developing solutions for hospital information systems. During this time, the company has made to all projects in-depth knowledge, experience and functionality of the systems HIS HP-1 and HP-HIS2, in more than one hundred hospitals throughout Spain.
Only in the last year information systems the company has managed to control were 1,200,000 hospitalizations, stays 9,450,000, 5,400,000 emergency interventions and 800,000 citations 25000000.
Moreover, Spain is a place of reference worldwide, with a competence center with over 150 health professionals.
About the Hospital de Sant Boi
Hospital de Sant Boi, opened in 1978, accumulating 30 years within the health sector and several people attending the Baix Llobregat. In January 2006, the Hospitaller Order of St John of God Hospital and acquire new management promotes a strategic plan in promoting organizational values and based on the quality of care. The new hospital will provide more and better health coverage, promoting the welfare of our users.
About HP
HP, the technology company world's largest IT products and services offered by printing and personal computing, software and solutions that provide the best technology experience for consumers and businesses. HP completed its acquisition of EDS on August 26, 2008. More information about HP (NYSE: HPQ) is available at http://www.hp.com.
The project involves a total investment of more than 800,000 euros
Hospital de Sant Boi, part of the Hospitaller Order of St John of God, he has more than 800,000 euros to the implementation of electronic patient record, with the help of HP. This project, which involves deploying HP-HCIS, the integrated information system for the health sector of Hewlett-Packard, and consolidate hospital andalusia andalusia andalusia owned group as a reference in the field of ICT sector.
According to Dr. Ramón Rosa, Managing Director of the Hospital de Sant Boi, "This project represents a transformation in the current management of the center and meets the need of providing quality care to the population. On the other hand, provides a flexibility in the care process, ensuring maximum security and confidentiality of information. This project, which encompasses the whole organization, is the result of commitment to the demands of today's society. Not only do we want to improve the structure, but we seek professional excellence to provide the reference population. "
A project in two phases
The introduction of HP-HCIS assumed that the health center to become one of the most advanced from a technological point of view, which would have identified two distinct phases. A first "administrative" to be held in nine months, which will carry out the deployment of administrative tools that are responsible for all efforts that affect the patients. Among them, the modules of hospital admissions and emergency summons, filing of medical records or management of waiting lists and surgical block.
Once this process is beginning a second phase "clinic", which will put everything on the history of the patients, the Clinical Work Station, Applications Manager, Protocolos Care Nursing Clinics and different trajectories care management tools. The entire project will be completed before the transfer from hospital to a new and modern facilities being built, and double its current capacity.
"Increasingly, health centers that are bidding for the HP-HCIS time to implement the electronic patient record," says Enrique Solbes, Director of HP Consulting & Integration for Spain and Portugal. "Undoubtedly, this agreement with the Hospital de Sant Boi is going to allow this center to become consolidated as one of the most advanced from a technological point of view, and that HP is still contributing to the continuous improvement of the Spanish health system."
More than 20 years of experience in the health sector
HP Spanish has about 20 years of experience in developing solutions for hospital information systems. During this time, the company has made to all projects in-depth knowledge, experience and functionality of the systems HIS HP-1 and HP-HIS2, in more than one hundred hospitals throughout Spain.
Only in the last year information systems the company has managed to control were 1,200,000 hospitalizations, stays 9,450,000, 5,400,000 emergency interventions and 800,000 citations 25000000.
Moreover, Spain is a place of reference worldwide, with a competence center with over 150 health professionals.
About the Hospital de Sant Boi
Hospital de Sant Boi, opened in 1978, accumulating 30 years within the health sector and several people attending the Baix Llobregat. In January 2006, the Hospitaller Order of St John of God Hospital and acquire new management promotes a strategic plan in promoting organizational values and based on the quality of care. The new hospital will provide more and better health coverage, promoting the welfare of our users.
About HP
HP, the technology company world's largest IT products and services offered by printing and personal computing, software and solutions that provide the best technology experience for consumers and businesses. HP completed its acquisition of EDS on August 26, 2008. More information about HP (NYSE: HPQ) is available at http://www.hp.com.
Technology Spanish, at the World Congress of Internal Medicine.
ITHACA-TSB and TSB Solutions presented their main research-oriented monitoring of chronic patients and home hospitalization.
- Issues such as the use of devices to monitor chronically ill patients using mobile devices and wireless technology aroused great interest to the attendees.
Last September, ending in Buenos Aires on 29 th World Congress of Internal Medicine. With more than 10,000 sessions of Congress and 85 clinics, was a resounding success in terms of participation and the quality and quantity of papers and communications.
In this context, Dr. Ignacio Basagoiti presented the paper "Technology and computer in the monitoring of patients and quality of life", which outlined the major developments and research ITACA-TSB Group of the Polytechnic University of Valencia, as well as of products developed by its spin-off TSB solutions.
Thus, issues such as the use of devices to monitor chronically ill patients using wireless technology and mobile devices as "derma rolling" to monitor skin lesions, cardiovascular disease Ritmus for mobile, MSV for monitoring vital signs, for SPHERAmobile the location and identification, aroused great interest to the attendees.
Similarly, TSB Solutions submitted its application in development for Home hospitalization units. The system is optimized in a way that facilitates the daily work and gives the unit more efficient, providing quick access from anywhere on the structured clinical information, thus avoiding problems such as duplication, loss of data or transcription errors and facilitating communication and integration with other information systems. This solution is currently deployed at Hospital La Fe (Valencia), Hospital Virgen de los Lirios (Alcoy) and Hospital Marqués de Valdecilla (Santander). Furthermore, it showed how solutions with TSB-TSB ITACA are participating in the construction of functional modules related to inpatient units to address the corporate agenda of the Generalitat Valenciana, ORION.
Finally, Dr. Basagoiti presented new research group, highlighting the developments in Web 2.0 based on a philosophy of patient-centered medicine. Specifically, the project Salupedia developed with funding from the Ministry of Industry within the forward plan for digital content, aims to provide patients and citizens in general health information quality recommended and selected by a community of health professionals, so that to constitute a complete open and collaborative medical encyclopedia.
About ITACA-TSB
ITHACA-TSB is a group of excellence dedicated to the development and transfer of applications of new technologies for improving quality of life: telemedicine and e-health, e-inclusion and infoaccesibilidad, Ambient Intelligence (AMI), health information, Quality Web.
ITHACA-TSB plans to implement initiatives to promote health, specifically on issues such as physical activity and healthy eating habits, creating scenarios where integration techniques are telemonitorización vital signs, knowledge management, application of motivational strategies, and much more .
TSB ITACA belongs to the Institute of the Polytechnic University of Valencia, and worked in major European projects such as Metabo, Persona, PIPS, My Heart, Oasis, etc.. It also offers solutions for institutions and companies as Educasalud (Fundación Telefónica), Digital Cities (Albany, Santander), WiMax (Ayto Sagunto), home hospitalization (Hospital La Fe), Ambulatory Surgery (Hospital Dr. Peset, etc.).
About TSB Solutions
TSB Solutions Inc. is a company dedicated to introducing and developing new technologies for personalized health care and welfare, improving the quality of life and creating new business opportunities based on their technological capabilities and research.
TSB Solutions Inc. Founded in January 2008 as a spin-off of the Institute ITACA of the Polytechnic University of Valencia. Based on the experience of over ten years of research for health-sector partner, and thanks to its structure and alliances, TSB SOLUTIONS SA has the capacity to effectively assess and exploit the business potential of R & D more relevant to the sector, bringing to the market new products and solutions that meet the demands of our customers.
Furthermore TSB SOLUTIONS S.A. has an extensive network of personal and professional relationships with Spanish, European and multinational, with the government, with NGOs and funding agencies of the R & D, developed in the framework of research projects and contracts made, giving TSB SOLUTIONS SA a broad and deep state of technology, our skills and market to which we are going.
Websites
- ITHACA-http://www.tsb.upv.es TSB.
- TSB Solutions http://www.tsbsoluciones.com.
- Issues such as the use of devices to monitor chronically ill patients using mobile devices and wireless technology aroused great interest to the attendees.
Last September, ending in Buenos Aires on 29 th World Congress of Internal Medicine. With more than 10,000 sessions of Congress and 85 clinics, was a resounding success in terms of participation and the quality and quantity of papers and communications.
In this context, Dr. Ignacio Basagoiti presented the paper "Technology and computer in the monitoring of patients and quality of life", which outlined the major developments and research ITACA-TSB Group of the Polytechnic University of Valencia, as well as of products developed by its spin-off TSB solutions.
Thus, issues such as the use of devices to monitor chronically ill patients using wireless technology and mobile devices as "derma rolling" to monitor skin lesions, cardiovascular disease Ritmus for mobile, MSV for monitoring vital signs, for SPHERAmobile the location and identification, aroused great interest to the attendees.
Similarly, TSB Solutions submitted its application in development for Home hospitalization units. The system is optimized in a way that facilitates the daily work and gives the unit more efficient, providing quick access from anywhere on the structured clinical information, thus avoiding problems such as duplication, loss of data or transcription errors and facilitating communication and integration with other information systems. This solution is currently deployed at Hospital La Fe (Valencia), Hospital Virgen de los Lirios (Alcoy) and Hospital Marqués de Valdecilla (Santander). Furthermore, it showed how solutions with TSB-TSB ITACA are participating in the construction of functional modules related to inpatient units to address the corporate agenda of the Generalitat Valenciana, ORION.
Finally, Dr. Basagoiti presented new research group, highlighting the developments in Web 2.0 based on a philosophy of patient-centered medicine. Specifically, the project Salupedia developed with funding from the Ministry of Industry within the forward plan for digital content, aims to provide patients and citizens in general health information quality recommended and selected by a community of health professionals, so that to constitute a complete open and collaborative medical encyclopedia.
About ITACA-TSB
ITHACA-TSB is a group of excellence dedicated to the development and transfer of applications of new technologies for improving quality of life: telemedicine and e-health, e-inclusion and infoaccesibilidad, Ambient Intelligence (AMI), health information, Quality Web.
ITHACA-TSB plans to implement initiatives to promote health, specifically on issues such as physical activity and healthy eating habits, creating scenarios where integration techniques are telemonitorización vital signs, knowledge management, application of motivational strategies, and much more .
TSB ITACA belongs to the Institute of the Polytechnic University of Valencia, and worked in major European projects such as Metabo, Persona, PIPS, My Heart, Oasis, etc.. It also offers solutions for institutions and companies as Educasalud (Fundación Telefónica), Digital Cities (Albany, Santander), WiMax (Ayto Sagunto), home hospitalization (Hospital La Fe), Ambulatory Surgery (Hospital Dr. Peset, etc.).
About TSB Solutions
TSB Solutions Inc. is a company dedicated to introducing and developing new technologies for personalized health care and welfare, improving the quality of life and creating new business opportunities based on their technological capabilities and research.
TSB Solutions Inc. Founded in January 2008 as a spin-off of the Institute ITACA of the Polytechnic University of Valencia. Based on the experience of over ten years of research for health-sector partner, and thanks to its structure and alliances, TSB SOLUTIONS SA has the capacity to effectively assess and exploit the business potential of R & D more relevant to the sector, bringing to the market new products and solutions that meet the demands of our customers.
Furthermore TSB SOLUTIONS S.A. has an extensive network of personal and professional relationships with Spanish, European and multinational, with the government, with NGOs and funding agencies of the R & D, developed in the framework of research projects and contracts made, giving TSB SOLUTIONS SA a broad and deep state of technology, our skills and market to which we are going.
Websites
- ITHACA-http://www.tsb.upv.es TSB.
- TSB Solutions http://www.tsbsoluciones.com.
Saturday, February 14, 2009
Gilead outlining their research and development program for 2009.
The biopharmaceutical company presents its latest advances in clinical development during the telephone press conference on the financial results of 2008
Gilead Sciences, Inc. (Nasdaq: GILD), stressed during the telephone press conference on the financial performance of last year, the priorities of its clinical development program for 2009. Among the most significant upgrades include the agreement with the Food and Drug Administration (FDA) U.S. in the clinical development of the following products: elvitegravir, GS 9350 and the fixed dose regimen of elvitegravir GS + 9350 + Truvada ® (emtricitabine and tenofovir disoproxil fumarate). Moreover, the discussion has begun on the timing of communications darusentan clinics for 2009 and progress in the development of compounds to treat hepatitis C virus (HCV) and liver diseases.
"Currently the R & D program of Gilead, is wider than at any other time in our 21 years of history," said Dr. Norbert Bischofberger, Executive Vice President of Research and Development and Chief Scientist of Gilead Sciences. "As we enter 2009, we have several candidates for our product development portfolio, including several products that are about to enter Phase III studies and Phase II. Our efforts are directed to a certain therapeutic areas where we believe we are strongly positioned to move forward with our drug and the potential to become the best treatments of their kind. "
HIGHLIGHTS OF R & D PROGRAM FOR 2009:
Developing a new regime of one tablet per day for HIV
Gilead is developing elvitegravir, the integrase inhibitor under investigation for use in HIV patients treated with other antiretrovirals, the GS 9350, a new drug enhancer and a "four-in-one fixed dose (CDF, or fixed-dose combination) for people with HIV, which combines elvitegravir, GS 9350, tenofovir disoproxil fumarate and emtricitabine. Currently, the only once-daily drug is Atripla ® (efavirenz 600 mg / emtricitabine 200 mg / tenofovir disoproxil fumarate 300 mg), marketed in the U.S., Canada and Europe by Gilead Sciences and Bristol-Myers Squibb Company and distributed by Merck & Co. Inc. in 94 developing countries.
• The next scientific conference on HIV, Gilead will present the first data in humans in the compressed "in a four." Specifically, the results of Phase I on the leverage effect of the drug GS 9350, both as independent drug as part of the tablet "four-in-one with elvitegravir, tenofovir and emtricitabine.
• With the agreement of the FDA to proceed with the development agenda of the CDF, Gilead plans to initiate a Phase II study in naïve patients in the second quarter of 2009.
Advancing the treatment of liver disease
The 9450 GS is the main candidate of Gilead for the treatment of serious diseases of the liver. It is a novel caspase inhibitor in a daily dose to treat the inflammation and fibrosis, and HCV and non-alcoholic steatohepatitis (NASH).
The non-alcoholic steatohepatitis is a disease characterized by inflammation of the liver caused by an accumulation of fat. This condition is associated with obesity, high cholesterol and diabetes. The National Center for Infectious Diseases in U.S. predicts that by 2025 more than 25 million Americans are affected by this disease.
• The Phase IIa study that evaluated the safety, tolerability, efficacy and pharmacokinetics of GS 9450 in patients infected with HCV has been completed. The data from this study will be presented this year at a medical conference, and Gilead plans to begin a Phase IIb study in the second quarter.
• The Phase IIa study of GS 9450 in patients with non-alcoholic steatohepatitis, to evaluate its safety, tolerability, pharmacokinetics and efficacy was initiated in the third quarter of 2008. The results of this study are expected in the fourth quarter of 2009.
• Gilead is also evaluating a new polymerase inhibitor, the GS 9190, as a potential treatment for HCV. Is already underway in a Phase II study of GS 9190 in combination with pegylated interferon alfa 2a and ribavirin in patients infected with HCV (genotype 1).
Expanding the presence in the cardiovascular area
The main drug in cardiovascular research in the area is darusentan. This drug is an oral receptor antagonist of endothelin (ARE) to treat resistant hypertension. This disease affects approximately 2 to 3 million Americans who fail to reach an optimal blood pressure despite taking three treatments of hypertension drugs including a diuretic.
• The Phase III clinical trials, DAR 311 and DAR 312, waiting to be completed this year, Gilead and provides the data 311 of the DAR will be announced in the second quarter.
• In addition, Gilead is developing cicletanina for pulmonary arterial hypertension (PAH), since early 2009 expected to begin a Phase II clinical trial to assess the pattern of one and two daily doses. Cicletanina is an oral agent that is already approved in some European countries for the treatment of hypertension.
• In the second quarter of 2009, Gilead plans to initiate a Phase III study will evaluate ambrisentan, an oral AER for hypertension associated with idiopathic pulmonary fibrosis.
Identifying the priorities in the area of lung diseases
Gilead continues to focus its efforts on the development of aztreonam lysine for inhalation and ambrisentan to treat idiopathic pulmonary fibrosis. In addition, are evaluating the potential of GS 9310/11 for the treatment of cystic fibrosis and GS 9411 for lung disease.
• Gilead has recently initiated a Phase II study of aztreonam lysine for inhalation in patients with bronchiectasis.
• This month has started a Phase III study of ambrisentan for the treatm of idiopathic pulmonary fibrosis. The ARTEMIS study will include approximately 600 patients at 190 research centers in USA, Canada, Europe, Asia, New Zealand and Australia.
• In the fourth quarter of 2008, we initiated a Phase II study to evaluate the safety and efficacy of GS 9310/11, inhaled and co-formulated with fosfomycin and tobramycin for bacterial infections associated with cystic fibrosis.
• Gilead is also evaluating the safety and tolerability of GS 9411, a new blocker of the epithelial sodium channel is designed to increase airway hydration for treatment of lung disease. The Phase I study was initiated in the fourth quarter of 2008.
The drugs discussed in this press release are investigational and not yet proven its safety or efficacy in humans.
Truvada ® is a trademark owned by Gilead Sciences
Atripla ® is a trademark owned by Bristol-Myers Squibb and Gilead Sciences
About Gilead Sciences
Gilead Sciences is a biopharmaceutical company that is dedicated to discover, develop and commercialize innovative therapeutics in areas of medical need that have not been met. The company's mission is to advance the care of patients suffering from diseases that pose a threat to life. Headquartered in Foster City (California), Gilead operates in USA, Europe and Australia.
Gilead Sciences, Inc. (Nasdaq: GILD), stressed during the telephone press conference on the financial performance of last year, the priorities of its clinical development program for 2009. Among the most significant upgrades include the agreement with the Food and Drug Administration (FDA) U.S. in the clinical development of the following products: elvitegravir, GS 9350 and the fixed dose regimen of elvitegravir GS + 9350 + Truvada ® (emtricitabine and tenofovir disoproxil fumarate). Moreover, the discussion has begun on the timing of communications darusentan clinics for 2009 and progress in the development of compounds to treat hepatitis C virus (HCV) and liver diseases.
"Currently the R & D program of Gilead, is wider than at any other time in our 21 years of history," said Dr. Norbert Bischofberger, Executive Vice President of Research and Development and Chief Scientist of Gilead Sciences. "As we enter 2009, we have several candidates for our product development portfolio, including several products that are about to enter Phase III studies and Phase II. Our efforts are directed to a certain therapeutic areas where we believe we are strongly positioned to move forward with our drug and the potential to become the best treatments of their kind. "
HIGHLIGHTS OF R & D PROGRAM FOR 2009:
Developing a new regime of one tablet per day for HIV
Gilead is developing elvitegravir, the integrase inhibitor under investigation for use in HIV patients treated with other antiretrovirals, the GS 9350, a new drug enhancer and a "four-in-one fixed dose (CDF, or fixed-dose combination) for people with HIV, which combines elvitegravir, GS 9350, tenofovir disoproxil fumarate and emtricitabine. Currently, the only once-daily drug is Atripla ® (efavirenz 600 mg / emtricitabine 200 mg / tenofovir disoproxil fumarate 300 mg), marketed in the U.S., Canada and Europe by Gilead Sciences and Bristol-Myers Squibb Company and distributed by Merck & Co. Inc. in 94 developing countries.
• The next scientific conference on HIV, Gilead will present the first data in humans in the compressed "in a four." Specifically, the results of Phase I on the leverage effect of the drug GS 9350, both as independent drug as part of the tablet "four-in-one with elvitegravir, tenofovir and emtricitabine.
• With the agreement of the FDA to proceed with the development agenda of the CDF, Gilead plans to initiate a Phase II study in naïve patients in the second quarter of 2009.
Advancing the treatment of liver disease
The 9450 GS is the main candidate of Gilead for the treatment of serious diseases of the liver. It is a novel caspase inhibitor in a daily dose to treat the inflammation and fibrosis, and HCV and non-alcoholic steatohepatitis (NASH).
The non-alcoholic steatohepatitis is a disease characterized by inflammation of the liver caused by an accumulation of fat. This condition is associated with obesity, high cholesterol and diabetes. The National Center for Infectious Diseases in U.S. predicts that by 2025 more than 25 million Americans are affected by this disease.
• The Phase IIa study that evaluated the safety, tolerability, efficacy and pharmacokinetics of GS 9450 in patients infected with HCV has been completed. The data from this study will be presented this year at a medical conference, and Gilead plans to begin a Phase IIb study in the second quarter.
• The Phase IIa study of GS 9450 in patients with non-alcoholic steatohepatitis, to evaluate its safety, tolerability, pharmacokinetics and efficacy was initiated in the third quarter of 2008. The results of this study are expected in the fourth quarter of 2009.
• Gilead is also evaluating a new polymerase inhibitor, the GS 9190, as a potential treatment for HCV. Is already underway in a Phase II study of GS 9190 in combination with pegylated interferon alfa 2a and ribavirin in patients infected with HCV (genotype 1).
Expanding the presence in the cardiovascular area
The main drug in cardiovascular research in the area is darusentan. This drug is an oral receptor antagonist of endothelin (ARE) to treat resistant hypertension. This disease affects approximately 2 to 3 million Americans who fail to reach an optimal blood pressure despite taking three treatments of hypertension drugs including a diuretic.
• The Phase III clinical trials, DAR 311 and DAR 312, waiting to be completed this year, Gilead and provides the data 311 of the DAR will be announced in the second quarter.
• In addition, Gilead is developing cicletanina for pulmonary arterial hypertension (PAH), since early 2009 expected to begin a Phase II clinical trial to assess the pattern of one and two daily doses. Cicletanina is an oral agent that is already approved in some European countries for the treatment of hypertension.
• In the second quarter of 2009, Gilead plans to initiate a Phase III study will evaluate ambrisentan, an oral AER for hypertension associated with idiopathic pulmonary fibrosis.
Identifying the priorities in the area of lung diseases
Gilead continues to focus its efforts on the development of aztreonam lysine for inhalation and ambrisentan to treat idiopathic pulmonary fibrosis. In addition, are evaluating the potential of GS 9310/11 for the treatment of cystic fibrosis and GS 9411 for lung disease.
• Gilead has recently initiated a Phase II study of aztreonam lysine for inhalation in patients with bronchiectasis.
• This month has started a Phase III study of ambrisentan for the treatm of idiopathic pulmonary fibrosis. The ARTEMIS study will include approximately 600 patients at 190 research centers in USA, Canada, Europe, Asia, New Zealand and Australia.
• In the fourth quarter of 2008, we initiated a Phase II study to evaluate the safety and efficacy of GS 9310/11, inhaled and co-formulated with fosfomycin and tobramycin for bacterial infections associated with cystic fibrosis.
• Gilead is also evaluating the safety and tolerability of GS 9411, a new blocker of the epithelial sodium channel is designed to increase airway hydration for treatment of lung disease. The Phase I study was initiated in the fourth quarter of 2008.
The drugs discussed in this press release are investigational and not yet proven its safety or efficacy in humans.
Truvada ® is a trademark owned by Gilead Sciences
Atripla ® is a trademark owned by Bristol-Myers Squibb and Gilead Sciences
About Gilead Sciences
Gilead Sciences is a biopharmaceutical company that is dedicated to discover, develop and commercialize innovative therapeutics in areas of medical need that have not been met. The company's mission is to advance the care of patients suffering from diseases that pose a threat to life. Headquartered in Foster City (California), Gilead operates in USA, Europe and Australia.
Laser hair removal is becoming the ultimate solution against sacral fistulas and abscesses.
The research results were published in the journal Dermatologic Surgery, the national expression of the American Society of Dermatology Surgery.
• Those affected by fistulas sacrocoxígeas, mostly boys between 15 and 40 years, have a possibility of recurrence nearly 40 percent, resulting in several cases subsequent surgeries in the same area.
• "All patients with this condition to which we have treated with laser hair removal have experienced a gradual and permanent resolution of the folliculitis, thus avoiding surgery.
• This type of procedure often requires a number of meetings varies depending on the patient and the cyst, but usually between three and eleven.
• "The laser hair removal should be considered as a treatment of choice for abscesses and fistulas sacrocoxígeas.
One of the major problems of those affected by abscesses and fistulas sacrocoxígeas, mostly boys between 15 and 40 years, is the high probability of relapse (a percentage close to 40 per cent). In contrast, laser hair removal interglúteo fold is an effective and durable treatment for folliculitis and reduce their risk of recurrence, thus avoiding a possible surgery.
Doctors Nerea Landa, José Luis Azpiazu have conducted an investigation in which the performance of the many treatments they have done to patients with recurrent fistulas Dermitek clinic in Bilbao since 1999. "Many patients have found an alternative to the traditional non-invasive surgery that provides a durable long-term outcome," says the dermatologist Nerea Landa. This study has been published in the journal Dermatologic Surgery, the national expression of the American Society of Dermatology Surgery. Still, "the scientific production in this area remains limited," say the authors.
The most severe cases of fistula sacrocoxígeas often require invasive treatments such as surgical excision or incision and drainage. When the infection is mild, treatment with an antibiotic or depilatory creams can be effective, although it is true, said Landa, who "unfortunately, in many cases the disease becomes a play and leads the patient to one, two or three surgeries. "
Avoid this constant, ie the usual recurrence, was the main objective of Dermitek investigators, who found in laser hair removal fold interglúteo a effective treatment against the sacral fistulas and abscesses in this area, "as the doctor Jose Luis Azpiazu.
Combining an alexandrite laser with intense pulsed light, have achieved "a progressive decline of infectious folliculitis-like hair loss in interglúteo-fold," says the dermatologist Nerea Landa. This type of treatment often requires a number of sessions varies, depending on the cyst and the patient, between three and eleven. In addition there have been no side effects in this study and, as Azpiazu, "has a high degree of satisfaction." Since Dermitek even say that "to date, none of the cases we have tried has been clarified further surgery because of this."
Prevention
One of the things that stand out from the investigation by Landa and Azpiazu is that data can be extrapolated to apply to medical prevention. "People whose parents have suffered sacral fistulas or abscesses have a high probability of ending the suffering that they, too," says the dermatologist.
Therefore, before the onset of symptoms prior to infection, which often manifest as a series of granite into the fold interglúteo, it is advisable to pluck the area because the hair just frozen in that area on many occasions in abscesses and subsequently recurrent sacral fistulas in the worst case, must be operated, with obvious discomfort and risks that this entails for those who suffer. "
A recurrent infection
The infectious folliculitis is characterized by frequent recurrences after treatment, and although it is known that the main determinant in their occurrence is due to the infection of hair frozen (along with other risk factors such as obesity and sweat frequently in interglútea area), is still not easy to prevent it. Despite this, physicians Dermitek out that "all patients with this condition to which we have treated with laser hair removal have experienced a gradual and permanent resolution of the folliculitis.
Among those affected by this pathology is the group of athletes, and ensures that as Azpiazu "is a condition that occurs frequently in certain sports," who adds that "athletes who have tried in the clinic have been a free problem that in most cases, have suffered for several years. "
Under the terms of the physicians, "laser hair removal should be considered as a treatment of choice for abscesses and fistulas sacrocoxígeas.
• Those affected by fistulas sacrocoxígeas, mostly boys between 15 and 40 years, have a possibility of recurrence nearly 40 percent, resulting in several cases subsequent surgeries in the same area.
• "All patients with this condition to which we have treated with laser hair removal have experienced a gradual and permanent resolution of the folliculitis, thus avoiding surgery.
• This type of procedure often requires a number of meetings varies depending on the patient and the cyst, but usually between three and eleven.
• "The laser hair removal should be considered as a treatment of choice for abscesses and fistulas sacrocoxígeas.
One of the major problems of those affected by abscesses and fistulas sacrocoxígeas, mostly boys between 15 and 40 years, is the high probability of relapse (a percentage close to 40 per cent). In contrast, laser hair removal interglúteo fold is an effective and durable treatment for folliculitis and reduce their risk of recurrence, thus avoiding a possible surgery.
Doctors Nerea Landa, José Luis Azpiazu have conducted an investigation in which the performance of the many treatments they have done to patients with recurrent fistulas Dermitek clinic in Bilbao since 1999. "Many patients have found an alternative to the traditional non-invasive surgery that provides a durable long-term outcome," says the dermatologist Nerea Landa. This study has been published in the journal Dermatologic Surgery, the national expression of the American Society of Dermatology Surgery. Still, "the scientific production in this area remains limited," say the authors.
The most severe cases of fistula sacrocoxígeas often require invasive treatments such as surgical excision or incision and drainage. When the infection is mild, treatment with an antibiotic or depilatory creams can be effective, although it is true, said Landa, who "unfortunately, in many cases the disease becomes a play and leads the patient to one, two or three surgeries. "
Avoid this constant, ie the usual recurrence, was the main objective of Dermitek investigators, who found in laser hair removal fold interglúteo a effective treatment against the sacral fistulas and abscesses in this area, "as the doctor Jose Luis Azpiazu.
Combining an alexandrite laser with intense pulsed light, have achieved "a progressive decline of infectious folliculitis-like hair loss in interglúteo-fold," says the dermatologist Nerea Landa. This type of treatment often requires a number of sessions varies, depending on the cyst and the patient, between three and eleven. In addition there have been no side effects in this study and, as Azpiazu, "has a high degree of satisfaction." Since Dermitek even say that "to date, none of the cases we have tried has been clarified further surgery because of this."
Prevention
One of the things that stand out from the investigation by Landa and Azpiazu is that data can be extrapolated to apply to medical prevention. "People whose parents have suffered sacral fistulas or abscesses have a high probability of ending the suffering that they, too," says the dermatologist.
Therefore, before the onset of symptoms prior to infection, which often manifest as a series of granite into the fold interglúteo, it is advisable to pluck the area because the hair just frozen in that area on many occasions in abscesses and subsequently recurrent sacral fistulas in the worst case, must be operated, with obvious discomfort and risks that this entails for those who suffer. "
A recurrent infection
The infectious folliculitis is characterized by frequent recurrences after treatment, and although it is known that the main determinant in their occurrence is due to the infection of hair frozen (along with other risk factors such as obesity and sweat frequently in interglútea area), is still not easy to prevent it. Despite this, physicians Dermitek out that "all patients with this condition to which we have treated with laser hair removal have experienced a gradual and permanent resolution of the folliculitis.
Among those affected by this pathology is the group of athletes, and ensures that as Azpiazu "is a condition that occurs frequently in certain sports," who adds that "athletes who have tried in the clinic have been a free problem that in most cases, have suffered for several years. "
Under the terms of the physicians, "laser hair removal should be considered as a treatment of choice for abscesses and fistulas sacrocoxígeas.
The SEIMC warning about the increase of sexually transmitted infections in Spain.
• Cases of syphilis have doubled in Spain in just a decade, according to the Spanish Society of Clinical Microbiology and Infectious Diseases (SEIMC)
• Infections by the human papilloma virus, in 15 years, have increased in our country nearly 50% among men and among women has tripled
• STIs have risen in our country due to changes in social behavior, migration and travel abroad
The Spanish Society of Clinical Microbiology and Infectious Diseases (SEIMC), which comprises the vast majority of clinical microbiologists and infectious disease specialists Spanish, warning about the increasing cases of sexually transmitted infections in our country in the last 10 years.
According to the World Health Organization syphilis, gonorrhea, chlamydia and trichomonas the daily affect more than one million people each year, appearing 340 million new cases. In Spain, syphilis is a disease that has increased because, in just ten years, due to this infection cases have come to achieving the 1734, doubling in just one decade.
A person suffering from an infection when a microorganism (virus, bacterium or parasite) is present in your body. The infected person does not necessarily have to have symptoms, do not feel sick, but transmits the organism causing the infection. Sexually transmitted infections are spread during sexual intercourse with infected and unprotected.
STD in our country
According to the ITS units of Oviedo and Gijón, dependent Monte Naranco Hospital of Oviedo, infection with human papilloma virus affected the late eighties, to 55,000 men and 10,000 women, while 15 years later the number of cases has risen by 50% among men and among women has tripled. According to Dr. Fernando Vazquez, section chief of the Hospital Basic Services Monte Naranco and member of the SEIMC: "Sexually transmitted infections spread, among other things, for lack of being infected because the symptoms are not easily detectable . If you recognize any symptoms or have unprotected sex or non-partners is necessary to apply as soon as possible to the doctor to a specialist in ITS, a microbiologist and infectologists or specialists such as gynecologists, dermatologists or urologists.
Similarly, STI services in this hospital have warned about the increasing cases of people infected with gonorrhea and chlamydia. After ten years getting Decreasing numbers, it appears that since 2000 they have gradually increased in both men and women. Both are infections that affect the urethra, in the case of men, and cervix in women. These two diseases affect more to gay men than heterosexuals and 8% of prostitutes in the case of chlamydia in our country. According to Dr. Vázquez, "The best way to avoid this type of disease in sexually active with multiple partners is the protection of condoms through the barrier more effectively, other methods are not as spermicidal creams and pessaries . Moreover, it is essential to avoid sex with people who have STIs until completely cured. "
A worrying increase
STIs have risen in the last 10 years, both in our country as elsewhere in the world due to various reasons such as changes in social behavior, migration and travel abroad. Such issues have fostered the resurgence of sexually transmitted infections such as lymphogranuloma venereum, more common in countries in tropical and subtropical climates, and that Spain had virtually disappeared.
The SEIMC updated for years and clinical protocols for diagnosis of sexually transmitted infections because of the importance of these diseases today. From the standpoint of diagnosis, he has improved with the application of new technologies such as molecular techniques are more sensitive and allow you to use non-invasive samples such as urine also has improved ability to detect resistant microorganisms antibiotics and rapid diagnostic techniques. The effort of the Company is currently focused on research, information and awareness about the risk of infection by this type of infection because the increased number of cases has increased dramatically in our country.
The SEIMC
The Spanish Society of Clinical Microbiology and Infectious Diseases (SEIMC) is a scientific society that brings together professionals working in the field of infectious disease, both from a clinical point of view as the diagnosis, treatment and prevention processes infectious.
The main purpose of the SEIMC is to foster, promote and disseminate the study and investigation of the Infectious Diseases and Clinical Microbiology, in terms of epidemiology, pathogenesis, diagnosis, treatment, prevention and control is concerned, as well as their interrelations .
Currently with over 2,400 partners, over 1,400 are for the section of Clinical Microbiology and about 1000 to the Infectious Diseases.
For more information, visit the websites:
http://www.seimc.org/inicio/index.asp
• Infections by the human papilloma virus, in 15 years, have increased in our country nearly 50% among men and among women has tripled
• STIs have risen in our country due to changes in social behavior, migration and travel abroad
The Spanish Society of Clinical Microbiology and Infectious Diseases (SEIMC), which comprises the vast majority of clinical microbiologists and infectious disease specialists Spanish, warning about the increasing cases of sexually transmitted infections in our country in the last 10 years.
According to the World Health Organization syphilis, gonorrhea, chlamydia and trichomonas the daily affect more than one million people each year, appearing 340 million new cases. In Spain, syphilis is a disease that has increased because, in just ten years, due to this infection cases have come to achieving the 1734, doubling in just one decade.
A person suffering from an infection when a microorganism (virus, bacterium or parasite) is present in your body. The infected person does not necessarily have to have symptoms, do not feel sick, but transmits the organism causing the infection. Sexually transmitted infections are spread during sexual intercourse with infected and unprotected.
STD in our country
According to the ITS units of Oviedo and Gijón, dependent Monte Naranco Hospital of Oviedo, infection with human papilloma virus affected the late eighties, to 55,000 men and 10,000 women, while 15 years later the number of cases has risen by 50% among men and among women has tripled. According to Dr. Fernando Vazquez, section chief of the Hospital Basic Services Monte Naranco and member of the SEIMC: "Sexually transmitted infections spread, among other things, for lack of being infected because the symptoms are not easily detectable . If you recognize any symptoms or have unprotected sex or non-partners is necessary to apply as soon as possible to the doctor to a specialist in ITS, a microbiologist and infectologists or specialists such as gynecologists, dermatologists or urologists.
Similarly, STI services in this hospital have warned about the increasing cases of people infected with gonorrhea and chlamydia. After ten years getting Decreasing numbers, it appears that since 2000 they have gradually increased in both men and women. Both are infections that affect the urethra, in the case of men, and cervix in women. These two diseases affect more to gay men than heterosexuals and 8% of prostitutes in the case of chlamydia in our country. According to Dr. Vázquez, "The best way to avoid this type of disease in sexually active with multiple partners is the protection of condoms through the barrier more effectively, other methods are not as spermicidal creams and pessaries . Moreover, it is essential to avoid sex with people who have STIs until completely cured. "
A worrying increase
STIs have risen in the last 10 years, both in our country as elsewhere in the world due to various reasons such as changes in social behavior, migration and travel abroad. Such issues have fostered the resurgence of sexually transmitted infections such as lymphogranuloma venereum, more common in countries in tropical and subtropical climates, and that Spain had virtually disappeared.
The SEIMC updated for years and clinical protocols for diagnosis of sexually transmitted infections because of the importance of these diseases today. From the standpoint of diagnosis, he has improved with the application of new technologies such as molecular techniques are more sensitive and allow you to use non-invasive samples such as urine also has improved ability to detect resistant microorganisms antibiotics and rapid diagnostic techniques. The effort of the Company is currently focused on research, information and awareness about the risk of infection by this type of infection because the increased number of cases has increased dramatically in our country.
The SEIMC
The Spanish Society of Clinical Microbiology and Infectious Diseases (SEIMC) is a scientific society that brings together professionals working in the field of infectious disease, both from a clinical point of view as the diagnosis, treatment and prevention processes infectious.
The main purpose of the SEIMC is to foster, promote and disseminate the study and investigation of the Infectious Diseases and Clinical Microbiology, in terms of epidemiology, pathogenesis, diagnosis, treatment, prevention and control is concerned, as well as their interrelations .
Currently with over 2,400 partners, over 1,400 are for the section of Clinical Microbiology and about 1000 to the Infectious Diseases.
For more information, visit the websites:
http://www.seimc.org/inicio/index.asp
Solilaser Group - Leaders in the medical-aesthetic
Solilaser Group is a group of companies engaged in product distribution of the medical-aesthetic and physical sports. Group is a dynamic, flexible, efficient and energetic, which was established in April 2001 in Girona by professionals with over 15 years of experience and established track record in the medical-aesthetic.
OUR VALUES
- Providing quality products and services, continuous improvement
- Reliability and commitment
- At the forefront of technology
- Provide results
- Customer Support and full commitment
- Personalization
PHILOSOPHY
- Contribute to improve physical and aesthetic for people using non-invasive, painless and non-ablative.
KEY SUCCESS
- Confidence in our products
- Collaboration with major manufacturer
- Latest Technology
- Medical Studies
- Actual Results
- Logistics carefully
- Reliability and quality, continuous improvement
- Marketing support for our customers
- A shared philosophy with the final
Solilaser Group's headquarters is located in Fornells de la Selva, Girona, and more than 1100 m2 where the Technical Service, a fully equipped training rooms, as well as a team to provide a service according to their needs.
OUR VALUES
- Providing quality products and services, continuous improvement
- Reliability and commitment
- At the forefront of technology
- Provide results
- Customer Support and full commitment
- Personalization
PHILOSOPHY
- Contribute to improve physical and aesthetic for people using non-invasive, painless and non-ablative.
KEY SUCCESS
- Confidence in our products
- Collaboration with major manufacturer
- Latest Technology
- Medical Studies
- Actual Results
- Logistics carefully
- Reliability and quality, continuous improvement
- Marketing support for our customers
- A shared philosophy with the final
Solilaser Group's headquarters is located in Fornells de la Selva, Girona, and more than 1100 m2 where the Technical Service, a fully equipped training rooms, as well as a team to provide a service according to their needs.
Medical and pharmaceutical
We bring a wealth of experience and dedication in coordinating communications multilingual global medical and pharmaceutical sectors. Our commitment to the quality of translation and presentation of their papers regulated has given us a good reputation in terms of linguistic excellence in this technically challenging.
Customers include durable leading firms from all sectors, including:
* Medical laboratories, pharmaceutical and biotech
* Laboratory services
* Diagnosis
* Medical
* OEM
* Reported health
* Medical textiles
Our experience covers the management of common projects in one or more languages with all kinds of documentation:
* Regulatory affairs
* Clinical trials
* Information for patients
* Medical Research
* Marketing and Corporate Communications
* Laboratory manuals and flowcharts
* Packaging and labeling doctor
* Data Sheets for users
* Patents
* Websites
* Management of medical terminology
Please contact us for more information or a quote.
Customers include durable leading firms from all sectors, including:
* Medical laboratories, pharmaceutical and biotech
* Laboratory services
* Diagnosis
* Medical
* OEM
* Reported health
* Medical textiles
Our experience covers the management of common projects in one or more languages with all kinds of documentation:
* Regulatory affairs
* Clinical trials
* Information for patients
* Medical Research
* Marketing and Corporate Communications
* Laboratory manuals and flowcharts
* Packaging and labeling doctor
* Data Sheets for users
* Patents
* Websites
* Management of medical terminology
Please contact us for more information or a quote.
Wednesday, February 11, 2009
Europe's largest natural health center will open in Sile
ESTE talk at the meeting held 7 and thus to reconstruct the Bedrettin Dalan: Turkey, Europe's largest natural health center to meet, "he said. Yeditepe University Hospital Aesthetic Center "ESTE 7 Dermatokozmetoloji, Aesthetic, Laser and Anti-Aging Center" has been reorganized. Speaking in the center of aesthetic presentation of the Foundation Board of Trustees Chairman REQUEST Bedrettin Dalan, within one year, Europe's largest natural Sile Nature Club to open the health center, he said. Baghdad Street from important Aesthetic Center ESTE 7 due to restructuring at the meeting organized speaking Bedrettin Dalan, ESTE 7 Yeditepe University Hospital a center of power as the greatest cause of the people's natural needs of the scientific and medical provision as that by saving the world with within the center of the most advanced aesthetic treatment devices have been told to win. Yeditepe University Poliklinik Baghdad Street in front of the start of the center is a highlight Bedrettin Dalan, 1 year later in Sile REQUEST Foundation Nature Club in Europe's largest Natural Health Center will add to the question was. Beijing city of China's largest natural health center in the world to establish cooperation with anlatan Bedrettin Dalan, Turkey, Europe's anti-aging treatment center will bring into light with tedavisiDermatolog Dr vurguladı.Yoğun atım. Müge Güler Özden also ESTE about 7 feet of aging (skin replacement), to Killa (Laser Hair Removal), spider veins treatment, capillary Hemanjiom (wine stain), Telenjektaziler (capillary vessels, rose disease, etc..), Sun spots and age spots and , warts and Nedbe (scar) tissue (especially acne scars) treatment dermatology experts and by estetisyenler successfully been applied to attract attention, the Center's the big difference of the laser therapy with intensive atım with light therapy combined with the implementation of the high capture success is reported. Dr. Özden, "ESTE 7, in conjunction with laser therapy with intensive light therapy atım achieve great success together with kullananılması are," he spoke. Beauty Expert Sirel Ertan, ESTE 7 for Yeditepe University Hospital in collaboration with the stated will serve as the powerful plastic surgery team, and Anti-Aging treatment is needed in all sectors related to other experts in the service of patients will have underlining. Ertan, "Anti-Aging treatment is needed in all branches of the Yeditepe University Hospital will be behind us," he said.
Circumcision was found useful in Europe
Finally, the European Parliament has been registered by
Commission officials in the Parliament's Health Security Adamos Adamou Greek doctor, "all Muslim and Jewish women against sexually transmitted diseases more secure. Because all intercourse with the circumcised men, "he said. Gave an example: "For example in cancer of the uterus that causes the mouth to protect the best way HPV'den be circumcised men."
Medical Oncology of the European Communities held in Istanbul this year with the most extensive involvement 31st European experts in the fields of Medical Oncology Congress in the third day of the two names came to the fore. The first is a period of Representatives of Cyprus for membership of the Health Security Commission of the European Parliament now has the delegates Adamos Adamou'ydu ...
HEALTH İZLEYİN in the EU
30-year career in treating thousands of patients who have lung cancer 15 years ago after losing his uncle with cancer fight the decision in the field of political platforms, Dr. Adamou, Larnaka'da came into the world. Talk much better as a child say that the Turkish Adamou and half English, half Turkish're chatting ...
Even cancer patients in Europe is confronted with inequality Dr. Adamou, "at a rate of 30 per cent of cancer diseases in developed countries, at a rate of 70 percent in developing countries can be seen. In developing countries, 70 percent of patients in the doctor is the final stage, "he says. This is the cause of economic conditions and, therefore, go to regularly check is connected.
Oncology, and medical centers in operation in countries close to Turkey's EU has a position indicating Adamou, "in effect the EU's national monitoring and early detection programs must follow," he says. Of the population above 50 years of age in Europe, regularly checked that a 5-year de anlatan Adamou, 25 countries among EU members is an interesting comparison. The EU's 10 new members, 15 former members of cancer cases compared with the survival rate of 25 percent is lower than the Adamou, "to make use of health services and social rights that citizens of all countries should provide," he says.
CANCER TYPES 200 VAR
Cancer is the situation in the world with examples explains Adamou Africa. And on this continent 50 million cancer patients, says a single professional onkolojistin fall.
In the meantime, has more than 200 kinds of cancer in the early diagnosis and treatment is very important that Adamou, "Breast cancer at a rate of 75 percent as a possible treatment of cancer, early detection is very even this rate is further increased. Colon cancer is the treatment rate is now approaching 95'lere percent. Most effective treatment is early detection of cancer, "he is talking.
Most striking to the store to explain Adamou. Muslim and Jewish women with uterine cancer rate is very low compared to Western countries is in a specified level, the reason "for men to be circumcised, and uterine cervix cancer with oral sexually transmitted diseases are also seen less," he explains.
SO EVERY YEAR 240 THOUSAND WOMEN is I
HPV (Human Papilloma Virus) that sexual relations with a virus. Oral cancer and cancer of the uterus before the virus causes 80 percent of the changes.
Some studies in the United States 60-70 is the percentage of women HPV'nin seen. Last year, the greatest importance in the mouth of the uterus, vagina and vulva cancer is discovered to be factors emerged. Immune system, such an infection is cleared or within two years, but the more resistant types of HPV oral cancer of the cervix or genital area can cause other cancers.
As more than 50 percent of sexually active women in the one or more types of the infection HPV'nin traces are found in. Most clinical symptoms of this infection that does not. Type of infection, often or very close sexual contact can be sensual. Arising from cancer among women worldwide, the second most common cause of death as cancer of the mouth of the uterus, and 240 thousand deaths each year resulting in approximately half a million are diagnosed. While some types of cancer can lead to HPV'nin other leads to sexual disease.
Commission officials in the Parliament's Health Security Adamos Adamou Greek doctor, "all Muslim and Jewish women against sexually transmitted diseases more secure. Because all intercourse with the circumcised men, "he said. Gave an example: "For example in cancer of the uterus that causes the mouth to protect the best way HPV'den be circumcised men."
Medical Oncology of the European Communities held in Istanbul this year with the most extensive involvement 31st European experts in the fields of Medical Oncology Congress in the third day of the two names came to the fore. The first is a period of Representatives of Cyprus for membership of the Health Security Commission of the European Parliament now has the delegates Adamos Adamou'ydu ...
HEALTH İZLEYİN in the EU
30-year career in treating thousands of patients who have lung cancer 15 years ago after losing his uncle with cancer fight the decision in the field of political platforms, Dr. Adamou, Larnaka'da came into the world. Talk much better as a child say that the Turkish Adamou and half English, half Turkish're chatting ...
Even cancer patients in Europe is confronted with inequality Dr. Adamou, "at a rate of 30 per cent of cancer diseases in developed countries, at a rate of 70 percent in developing countries can be seen. In developing countries, 70 percent of patients in the doctor is the final stage, "he says. This is the cause of economic conditions and, therefore, go to regularly check is connected.
Oncology, and medical centers in operation in countries close to Turkey's EU has a position indicating Adamou, "in effect the EU's national monitoring and early detection programs must follow," he says. Of the population above 50 years of age in Europe, regularly checked that a 5-year de anlatan Adamou, 25 countries among EU members is an interesting comparison. The EU's 10 new members, 15 former members of cancer cases compared with the survival rate of 25 percent is lower than the Adamou, "to make use of health services and social rights that citizens of all countries should provide," he says.
CANCER TYPES 200 VAR
Cancer is the situation in the world with examples explains Adamou Africa. And on this continent 50 million cancer patients, says a single professional onkolojistin fall.
In the meantime, has more than 200 kinds of cancer in the early diagnosis and treatment is very important that Adamou, "Breast cancer at a rate of 75 percent as a possible treatment of cancer, early detection is very even this rate is further increased. Colon cancer is the treatment rate is now approaching 95'lere percent. Most effective treatment is early detection of cancer, "he is talking.
Most striking to the store to explain Adamou. Muslim and Jewish women with uterine cancer rate is very low compared to Western countries is in a specified level, the reason "for men to be circumcised, and uterine cervix cancer with oral sexually transmitted diseases are also seen less," he explains.
SO EVERY YEAR 240 THOUSAND WOMEN is I
HPV (Human Papilloma Virus) that sexual relations with a virus. Oral cancer and cancer of the uterus before the virus causes 80 percent of the changes.
Some studies in the United States 60-70 is the percentage of women HPV'nin seen. Last year, the greatest importance in the mouth of the uterus, vagina and vulva cancer is discovered to be factors emerged. Immune system, such an infection is cleared or within two years, but the more resistant types of HPV oral cancer of the cervix or genital area can cause other cancers.
As more than 50 percent of sexually active women in the one or more types of the infection HPV'nin traces are found in. Most clinical symptoms of this infection that does not. Type of infection, often or very close sexual contact can be sensual. Arising from cancer among women worldwide, the second most common cause of death as cancer of the mouth of the uterus, and 240 thousand deaths each year resulting in approximately half a million are diagnosed. While some types of cancer can lead to HPV'nin other leads to sexual disease.
Agreement was signed in Ankara, the European Heart Health
European Cardiology Derneği'nce prepared "European Heart Health Agreement", Ankara Provincial Health Directorate of the signing ceremony was held in Ostim'deki outbuilding. Contract, Health Minister Recep Akdag as well as Turkish Cardiology Association, Turkish Internal Medicine Specialist Association, Turkey Endocrinology and Metabolism Society, the Turkish Association of Pediatric Cardiology, Turkish Hypertension and Kidney Diseases Association, Turkey Physical Medicine and Rehabilitation Specialist Doctors Association, Rheumatism Research and War Association, the Turkish Cardiovascular Surgery Society, and was signed by representatives of the Turkish Society of Neurology. Akdağ Minister, in his speech at the ceremony in the country caused the death of one of every 2 people that are the heart-vascular diseases, the chronic disease seen around the world indicates that the frequency has increased. Apply the "Health Transformation Program" and the last 5 years, indicating that health-related priorities change Akdağ Minister, now more than heart disease and cancer has come to the fore.
Health promotion and development
Equitable, fair, equitable and people-oriented with a system based on the Health Transformation Program more closely with these issues is beginning to express interest the Akdağ Obesity in 2006 by the European Anti document was signed in Turkey reminded. Akdağ Minister, it has continued as follows: "Health related development programs in the second period of the Health Transformation Program, will give high priority in the second 5-year period. About the Ministry General Directorate of Basic Health Services in two of our offices are established. One of them is the Department of Chronic Diseases, the other for Health Promotion and Development Department. "Healthy such as nutrition and smoking, despite the messages communicated in these areas are experiencing changes in the behavior-recording Akdağ Minister," to inform society, not enough to educate. By informing, training to increase awareness, but awareness of this change in behavior after leaving work to go up before we need to work, "he spoke. Excessive fatty foods, many meals consisting of vegetables and fruit instead of weighted emphasis to nutrition, light and healthy food where a nutrition habits point to the need to adopt the Akdag, the direction of children already also stressed the importance.
Emergency Service question
Increasing physical activity and smoking should be remote from the Minister Akdag said, "These three issues to be resolved if we ourselves are largely protected," he said. Universities, schools and the Turkish Armed Forces will do with this study indicating Akdağ issues, to support the needs of the organs of the media said. This stability is very important that the action In turn underlines the Akdağ prepared action plans on these issues with their associated execution said. Death is but the fatality is needed to prevent premature deaths declaratory Akdağ, especially related to heart health are available to do a lot. Health Minister Akdag, after meeting in emergency services from time to time problems will be remembered, "This is an issue about you?" Questions on the Health Transformation Program, one of the purposes for which patients have been shown more solicitude said. Emergency services, intensive care and about 112 service is taken seriously describe distances Akdag, the difficulties experienced in a hospital's general need says. After you begin the program in question to apply to the rights of citizens, search and retrieve service improvements recording conditions Akdağ Minister, but said the problems were also ignored. The emergency services for citizens only want to apply for emergency diseases Akdağ, "Citizens and non-emergency illnesses should not take the road of emergency. Today we all know very well that our people receive health services have improved the conditions to be compared. But sometimes problems can occur. We strive to provide a service that is more perfect. Emergency services, emergency health for our citizens only need apply. In Turkey, we have the wrong habits. Examination of the patient 20 per cent is applied to after-hours emergency service. This is increasing the workload of emergency services. Imagine a thousand patients a day emergency service is accepted, this time there is really very urgent situation of the patient's services business is getting difficult. Emergency non-emergency services to take the road to disease. Doctors to treat patients better in-service training is ongoing. Individual errors are not true examples. In general, the system I'm interested to see where it got, "he spoke.
"We must raise awareness"
Turkish Society of Cardiology Prof. Dr. Why is it necessary to tell Cetin Erol a contract, the cardiac-vascular diseases in Europe, said it was the first cause of death. World Health Organization (WHO) European Region in the country in 52 years on the 4:35 million, from 1.9 million in the EU is responsible for more deaths than heart disease in the EU countries the cost of 169 billion Euros is Prof. save. Dr. Erol, Convention and EU countries in the WHO European Region is to reduce the burden of cardiovascular disease has been reported to target. Prof. Dr. Erol, for the social mobilization declared by establishing broad-based coalition, the need to increase awareness by using the mass media and social marketing, community and patients by developing and strengthening the training activities is intended to make, he said.
Health promotion and development
Equitable, fair, equitable and people-oriented with a system based on the Health Transformation Program more closely with these issues is beginning to express interest the Akdağ Obesity in 2006 by the European Anti document was signed in Turkey reminded. Akdağ Minister, it has continued as follows: "Health related development programs in the second period of the Health Transformation Program, will give high priority in the second 5-year period. About the Ministry General Directorate of Basic Health Services in two of our offices are established. One of them is the Department of Chronic Diseases, the other for Health Promotion and Development Department. "Healthy such as nutrition and smoking, despite the messages communicated in these areas are experiencing changes in the behavior-recording Akdağ Minister," to inform society, not enough to educate. By informing, training to increase awareness, but awareness of this change in behavior after leaving work to go up before we need to work, "he spoke. Excessive fatty foods, many meals consisting of vegetables and fruit instead of weighted emphasis to nutrition, light and healthy food where a nutrition habits point to the need to adopt the Akdag, the direction of children already also stressed the importance.
Emergency Service question
Increasing physical activity and smoking should be remote from the Minister Akdag said, "These three issues to be resolved if we ourselves are largely protected," he said. Universities, schools and the Turkish Armed Forces will do with this study indicating Akdağ issues, to support the needs of the organs of the media said. This stability is very important that the action In turn underlines the Akdağ prepared action plans on these issues with their associated execution said. Death is but the fatality is needed to prevent premature deaths declaratory Akdağ, especially related to heart health are available to do a lot. Health Minister Akdag, after meeting in emergency services from time to time problems will be remembered, "This is an issue about you?" Questions on the Health Transformation Program, one of the purposes for which patients have been shown more solicitude said. Emergency services, intensive care and about 112 service is taken seriously describe distances Akdag, the difficulties experienced in a hospital's general need says. After you begin the program in question to apply to the rights of citizens, search and retrieve service improvements recording conditions Akdağ Minister, but said the problems were also ignored. The emergency services for citizens only want to apply for emergency diseases Akdağ, "Citizens and non-emergency illnesses should not take the road of emergency. Today we all know very well that our people receive health services have improved the conditions to be compared. But sometimes problems can occur. We strive to provide a service that is more perfect. Emergency services, emergency health for our citizens only need apply. In Turkey, we have the wrong habits. Examination of the patient 20 per cent is applied to after-hours emergency service. This is increasing the workload of emergency services. Imagine a thousand patients a day emergency service is accepted, this time there is really very urgent situation of the patient's services business is getting difficult. Emergency non-emergency services to take the road to disease. Doctors to treat patients better in-service training is ongoing. Individual errors are not true examples. In general, the system I'm interested to see where it got, "he spoke.
"We must raise awareness"
Turkish Society of Cardiology Prof. Dr. Why is it necessary to tell Cetin Erol a contract, the cardiac-vascular diseases in Europe, said it was the first cause of death. World Health Organization (WHO) European Region in the country in 52 years on the 4:35 million, from 1.9 million in the EU is responsible for more deaths than heart disease in the EU countries the cost of 169 billion Euros is Prof. save. Dr. Erol, Convention and EU countries in the WHO European Region is to reduce the burden of cardiovascular disease has been reported to target. Prof. Dr. Erol, for the social mobilization declared by establishing broad-based coalition, the need to increase awareness by using the mass media and social marketing, community and patients by developing and strengthening the training activities is intended to make, he said.
In IZMIR CONGRESS OF THE EUROPEAN RADYOLOgy
In a different European city each year are performed, and the European Radiology Congress in 14'üncüsü this year did Izmir hosts. In the conference held in Hilton Hotel, 400 on the radiologist "Joint Disease and Treatment Roads" was discussed then. İncekara, Turkey's leading medical companies such as Simeks of Congress stand in the hall was open.
İzmir, this year the European 14'ncüsü Deposit - Skeletal System was host to the Congress of Radiology. Place between June 1-2 at the Hilton Hotel to the congress from domestic and abroad, over 400 attended radiologist. Turkey, Germany, the Netherlands, Belgium, United Kingdom from European countries such as providing notification of the radiologist in the session of Congress did not get press.
In a different European city each year, the congress chairman of the Department of Radiology, Medical Faculty of Ege University President Prof.. Dr. Remi was Arkun. Health Magazine provide information prior to the opening Kongenin Prof.. Dr. Remi Arkun, Congress's main topics of the shoulder joint and other joints in the body to highlight issues that the illnesses, "10 Turkish scientists in Congress and foreign scientists presented papers. In Turkey and the world of joint discomfort brought by developments in the exchange of information has been provided. Rheumatic diseases, bone tumors, sports injuries and treatment methods was discussed recognition, "he spoke.
America, Asia and North Africa countries, experts in the field of speaker presentations at the congress are performed, especially in the shoulder joint, the joint diseases, rheumatic disorders, bone and soft tissue tumors with sports injuries on issues on the table has been deposited, diagnosis and treatment, roads are discussed.
Hospitals and health institutions in Turkey's intensive participation in the Congress, the leading medical and pharmaceutical companies have introduced new products to open the stand. İncekara, such as companies that stand to open Simeks domestic and foreign scientists have introduced products.
İzmir, this year the European 14'ncüsü Deposit - Skeletal System was host to the Congress of Radiology. Place between June 1-2 at the Hilton Hotel to the congress from domestic and abroad, over 400 attended radiologist. Turkey, Germany, the Netherlands, Belgium, United Kingdom from European countries such as providing notification of the radiologist in the session of Congress did not get press.
In a different European city each year, the congress chairman of the Department of Radiology, Medical Faculty of Ege University President Prof.. Dr. Remi was Arkun. Health Magazine provide information prior to the opening Kongenin Prof.. Dr. Remi Arkun, Congress's main topics of the shoulder joint and other joints in the body to highlight issues that the illnesses, "10 Turkish scientists in Congress and foreign scientists presented papers. In Turkey and the world of joint discomfort brought by developments in the exchange of information has been provided. Rheumatic diseases, bone tumors, sports injuries and treatment methods was discussed recognition, "he spoke.
America, Asia and North Africa countries, experts in the field of speaker presentations at the congress are performed, especially in the shoulder joint, the joint diseases, rheumatic disorders, bone and soft tissue tumors with sports injuries on issues on the table has been deposited, diagnosis and treatment, roads are discussed.
Hospitals and health institutions in Turkey's intensive participation in the Congress, the leading medical and pharmaceutical companies have introduced new products to open the stand. İncekara, such as companies that stand to open Simeks domestic and foreign scientists have introduced products.
The brain surgeon has been opened in Europe
The brain surgeon has been opened to the European Union of European Medical Specialists, Uludağ University Faculty of Medicine of the specific training Nörüşirürji Clinic, is the European equivalent of the certificates given
Uludag University Medical Faculty Department of Neurosurgery, his specific training and the European Union of Medical Specialists has been accredited by the Neurosurgery Department. Accreditation process, particularly in academic staff members and experts have received training and qualification for the last 5 years have received training, attended conferences and seminars, they do the surgery number, diversity in all hospitals and clinics technical equipment, neurosurgery research laboratories of the adequacy of the basic issues in assessment got. Clinical accreditation certificate in the month of February 2006 at the meeting will be held in Luxembourg.
Uludag University Department of Neurosurgery Prof. Dr. Ender Korfalı, related to that, Uludağ University Faculty of Medicine of the Neurosurgery Clinic neurosurgeon in the field of education through the accreditation if they find jobs in Europe as a specialist could work, he said.
To be accredited in December 2003 stating that the contact Prof. Dr. Korfalı accreditation committee of experts, especially in the first clinical program director for the last 5 years have received training, do you evaluate the international publication has been expressed. Korfalı the committee also, hospital, clinical status of the operation of technical equipment used in compliance with European standards, research laboratories, such as the adequacy of the report is an evaluation of all the items reported.
European Union of Medical Specialists, the validity of accreditation every 5 years by a program director and the report is based on re-approve.
Uludag University Medical Faculty Department of Neurosurgery, his specific training and the European Union of Medical Specialists has been accredited by the Neurosurgery Department. Accreditation process, particularly in academic staff members and experts have received training and qualification for the last 5 years have received training, attended conferences and seminars, they do the surgery number, diversity in all hospitals and clinics technical equipment, neurosurgery research laboratories of the adequacy of the basic issues in assessment got. Clinical accreditation certificate in the month of February 2006 at the meeting will be held in Luxembourg.
Uludag University Department of Neurosurgery Prof. Dr. Ender Korfalı, related to that, Uludağ University Faculty of Medicine of the Neurosurgery Clinic neurosurgeon in the field of education through the accreditation if they find jobs in Europe as a specialist could work, he said.
To be accredited in December 2003 stating that the contact Prof. Dr. Korfalı accreditation committee of experts, especially in the first clinical program director for the last 5 years have received training, do you evaluate the international publication has been expressed. Korfalı the committee also, hospital, clinical status of the operation of technical equipment used in compliance with European standards, research laboratories, such as the adequacy of the report is an evaluation of all the items reported.
European Union of Medical Specialists, the validity of accreditation every 5 years by a program director and the report is based on re-approve.
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